ArticleBiophysical journal2013
Membrane tethered delta activates notch and reveals a role for spatio-mechanical regulation of the signaling pathway.
Article in Biophysical journal, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed, 50 citations in OpenAlex.
- Exclusion of Notch from the contact site during efferocytosis restricts anticancer immunity.Nature immunology · 2026Article
- Human Progenitor T-Cell Differentiation Regulated by the Mechanical Resistance of Thymus-Mimetic Extracellular Matrices.Advanced healthcare materials · 2026Article
- From iPSC to manufactured iNK cells using CombiCult® screening platform.Frontiers in cell and developmental biology · 2026Article
- Article
- Nuclease-Resistant L-DNA Tension Probes Enable Long-Term Force Mapping of Single Cells and Cell Consortia.Angewandte Chemie (International ed. in English) · 2024Article
- DNA mechanocapsules for programmable piconewton responsive drug delivery.Nature communications · 2024Article
- Soluble and multivalent Jag1 DNA origami nanopatterns activate Notch without pulling force.Nature communications · 2024Article
- Adherens junctions organize size-selective proteolytic hotspots critical for Notch signalling.Nature cell biology · 2022Article
- Engineering tissue morphogenesis: taking it up a Notch.Trends in biotechnology · 2022Review
- The magnitude of LFA-1/ICAM-1 forces fine-tune TCR-triggered T cell activation.Science advances · 2022Article
- Endothelial Notch signaling directly regulates the small GTPase RND1 to facilitate Notch suppression of endothelial migration.Scientific reports · 2022Article
- Immobilization of Jagged1 Enhances Vascular Smooth Muscle Cells Maturation by Activating the Notch Pathway.Cells · 2021Article
- To be more precise: the role of intracellular trafficking in development and pattern formation.Biochemical Society transactions · 2020Review
- Modelling cell surface dynamics and cell-cell interactions using Cell Studio: a three-dimensional visualization tool based on gaming technology.Journal of the Royal Society, Interface · 2019Article
- DNA mechanotechnology reveals that integrin receptors apply pN forces in podosomes on fluid substrates.Nature communications · 2019Article
- Influence of the Assembly State on the Functionality of a Supramolecular Jagged1-Mimicking Peptide Additive.ACS omega · 2019Article
- Spatiomechanical Modulation of EphB4-Ephrin-B2 Signaling in Neural Stem Cell Differentiation.Biophysical journal · 2018Article
- Platelet integrins exhibit anisotropic mechanosensing and harness piconewton forces to mediate platelet aggregation.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Supported lipid bilayer platforms to probe cell mechanobiology.Biochimica et biophysica acta. Biomembranes · 2017Review
- Immobilisation of Delta-like 1 ligand for the scalable and controlled manufacture of hematopoietic progenitor cells in a stirred bioreactor.BMC biotechnology · 2017Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Short-range Notch receptor signaling is necessary for coordinating developmental activities in metazoa. To investigate this juxtacrine pathway, we mimic receptor-ligand binding within the cell-cell junction by engaging Notch1-eGFP expressing cells to a supported lipid membrane displaying Delta-like protein 4 (DLL4). DLL4-Notch1 binding, oligomerization, and transport were observed in real time, and the molecular density and stoichiometry of the complexes were determined using quantitative fluorescence imaging. A Notch transcriptional reporter readout was used to quantify how ligand lateral mobility, orientation, and density modulate receptor activation levels. These experiments demonstrate that limiting the lateral mobility of DLL4 can enhance Notch activation by 2.6-fold, thus supporting the existence of a spatio-mechanical mechanism of signal regulation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.