ArticleGenome biology2013
Transcriptomics-based screen for genes induced by flagellin and repressed by pathogen effectors identifies a cell wall-associated kinase involved in plant immunity.
Article in Genome biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 83 papers.
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83 citing papers in PubMed, 182 citations in OpenAlex.
- Genome Wide Association Study Reveals Novel Loci Controlling Agronomic Traits in Tomato (Solanum lycopersicum L.).Biochemical genetics · 2026Article
- TheGenes · 2026Article
- Comparative transcriptome and genome analysis between susceptible Zhefang rice variety Diantun 502 and its resistance variety Diantun 506 upon Magnaporthe oryzae infection.BMC plant biology · 2025Article
- A cell wall-associated kinase phosphorylates NLR immune receptor to negatively regulate resistosome formation.Nature plants · 2025Article
- Polyphasic taxonomy and genome mining ofCurrent research in microbial sciences · 2025Article
- Engineering and application of multiepitope recombinant proteins to enhance resistance toFrontiers in plant science · 2025Article
- Natural variation in the pattern-triggered immunity response in plants: Investigations, implications and applications.Molecular plant pathology · 2024Review
- The ZmWAKL-ZmWIK-ZmBLK1-ZmRBOH4 module provides quantitative resistance to gray leaf spot in maize.Nature genetics · 2024Article
- Comparative transcriptome analysis of canola carrying a single vs stacked resistance genes against clubroot.Frontiers in plant science · 2024Article
- Structural diversity and stress regulation of the plant immunity-associated CALMODULIN-BINDING PROTEIN 60 (CBP60) family of transcription factors in Solanum lycopersicum (tomato).Functional & integrative genomics · 2023Article
- BABA-induced pathogen resistance: a multi-omics analysis of the tomato response reveals a hyper-receptive status involving ethylene.Horticulture research · 2023Article
- Loss-of-function mutations in WRKY22 and WRKY25 impair stomatal-mediated immunity and PTI and ETI responses against Pseudomonas syringae pv. tomato.Plant molecular biology · 2023Article
- Tomato receptor-like cytoplasmic kinase Fir1 is involved in flagellin signaling and preinvasion immunity.Plant physiology · 2023Article
- The WAK-like protein RFO1 acts as a sensor of the pectin methylation status in Arabidopsis cell walls to modulate root growth and defense.Molecular plant · 2023Article
- Genome-Wide Analysis of thePlants (Basel, Switzerland) · 2023Article
- Comparison of Tomato Transcriptomic Profiles Reveals Overlapping Patterns in Abiotic and Biotic Stress Responses.International journal of molecular sciences · 2023Article
- Genome-Wide Re-Identification and Analysis of CrRLK1Ls in Tomato.International journal of molecular sciences · 2023Article
- GmWAK1, Novel Wall-Associated Protein Kinase, Positively Regulates Response of Soybean toInternational journal of molecular sciences · 2023Article
- Comprehensive Analysis ofGenes · 2022Review
- Genome-Wide Identification and Expression Analysis of Wall-Associated Kinase (WAK) Gene Family inPlants (Basel, Switzerland) · 2022Article
23 more citing papers are in PubMed but not listed here.
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Authors and funding
8 authors at 5 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMicrobe-associated molecular patterns, such as those present in bacterial flagellin, are powerful inducers of the innate immune response in plants. Successful pathogens deliver virulence proteins, termed effectors, into the plant cell where they can interfere with the immune response and promote disease. Engineering the plant immune system to enhance disease resistance requires a thorough understanding of its components.
resultsWe describe a high-throughput screen, using RNA sequencing and virus-induced gene silencing, to identify tomato genes whose expression is enhanced by the flagellin microbe-associated molecular pattern flgII-28, but reduced by activities of the Pseudomonas syringae pv. tomato (Pst) type III effectors AvrPto and AvrPtoB. Gene ontology terms for this category of Flagellin-induced repressed by effectors (FIRE) genes showed enrichment for genes encoding certain subfamilies of protein kinases and transcription factors. At least 25 of the FIRE genes have been implicated previously in plant immunity. Of the 92 protein kinase-encoding FIRE genes, 33 were subjected to virus-induced gene silencing and their involvement in pattern-triggered immunity was tested with a leaf-based assay. Silencing of one FIRE gene, which encodes the cell wall-associated kinase SlWAK1, compromised the plant immune response resulting in increased growth of Pst and enhanced disease symptoms.
conclusionsOur transcriptomic approach identifies FIRE genes that represent a pathogen-defined core set of immune-related genes. The analysis of this set of candidate genes led to the discovery of a cell wall-associated kinase that participates in plant defense. The FIRE genes will be useful for further elucidation of the plant immune system.
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