ArticleBMC research notes2013
Levels of 25 cytokines in the first seven days of life in newborn infants.
Article in BMC research notes, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 47 citations in OpenAlex.
- Cytokine patterns in very low birth weight infants under different cord clamping strategies: preliminary EXPLAIN trial data.BMC pediatrics · 2026Trial
- The immune system of preterm infants: an overview.Frontiers in immunology · 2026Review
- Longitudinal inflammatory biomarker profiling in intrauterine growth restricted preterm infants.Cytokine · 2025Article
- Interleukin-2 gene methylation levels and interleukin-2 levels associated with environmental exposure as risk biomarkers for preterm birth.Croatian medical journal · 2023Article
- Inflammatory Biomarker Profiles in Very Preterm Infants within the Context of Preeclampsia, Chorioamnionitis, and Clinically Diagnosed Postnatal Infection.Pediatric reports · 2023Article
- Increased Expression of Anaphylatoxin C5a-Receptor-1 in Neutrophils and Natural Killer Cells of Preterm Infants.International journal of molecular sciences · 2023Article
- Chorioamnionitis-exposure alters serum cytokine trends in premature neonates.Journal of perinatology : official journal of the California Perinatal Association · 2023Article
- Perinatal Inflammatory Biomarkers and Respiratory Disease in Preterm Infants.The Journal of pediatrics · 2022Article
- Tools for assessing lung fluid in neonates with respiratory distress.BMC pediatrics · 2022Article
- Vascular network expansion, integrity of blood-brain interfaces, and cerebrospinal fluid cytokine concentration during postnatal development in the normal and jaundiced rat.Fluids and barriers of the CNS · 2022Article
- The association ofFrontiers in neurology · 2022Article
- Effect of washed versus unwashed red blood cells on transfusion-related immune responses in preterm newborns.Clinical & translational immunology · 2022Article
- Ontogeny of plasma cytokine and chemokine concentrations across the first week of human life.Cytokine · 2021Article
- Neonatal Encephalopathy Is Associated With Altered IL-8 and GM-CSF Which Correlates With Outcomes.Frontiers in pediatrics · 2020Article
- Clinical and Immunological Metrics During Pediatric Rhesus Macaque Development.Frontiers in pediatrics · 2020Article
- Exploration of potential biochemical markers for persistence of patent ductus arteriosus in preterm infants at 22-27 weeks' gestation.Pediatric research · 2019Observational
- A male preterm infant with cow's milk allergy to human milk fortifier showing only severe respiratory symptoms.Fukushima journal of medical science · 2019Article
- Necrotizing enterocolitis attenuates developmental heart rate variability increases in newborn rats.Neurogastroenterology and motility · 2019Article
- Observational
- Improved survival after induction of sepsis by cecal slurry in PD-1 knockout murine neonates.Surgery · 2017Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundNovel methods for cytokine analysis allow for the simultaneous measurement of 25 cytokines in 50 μL serum or plasma. Data on values of most of these cytokines in non-infected newborn infants are lacking. We analyzed levels of 25 cytokines in the first week of life in non-infected preterm and term infants and related them to gestational age.
findingsDuring the first week after birth, no trend over time was found in any of the cytokines, except for IL-1Ra and IL-6 where higher values were found in the first four hours. Between 24 and 72 hrs levels of IL-1Ra, IL-2, IL-8, IL-12, IL-13, IL-15, IL-17, IFNγ, MIP-1a, MCP-1, TNFα were lower in infants born after 30-32 wks compared to infants ≥ 36 wks; levels of IL-6, IL-10, IP-10 were lower in preterm infants of both 30-32 and 33-36 weeks. No difference between groups for any of the levels was found for IL-1b, IL-2r, IL-4, IL-5, IL-7, IFNa, MIP-1b, GM-CSF, Eotaxin and RANTES.
conclusionsLevels of 25 interleukines are stable in the first week of life in non-infected infants. Infants born after 30-32 wks showed lower levels of fourteen cytokines compared to infants born after more then 36 wks. This indicates a lower stimulation or activation of Th-1 cells, monocytes and dendritic cells in these infants.
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