ArticleCurrent Alzheimer research2014
Low plasma leptin in cognitively impaired ADNI subjects: gender differences and diagnostic and therapeutic potential.
Article in Current Alzheimer research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
33 citing papers in PubMed, 64 citations in OpenAlex.
- Leptin as a Potential Modifier of Neuroinflammation: Contrasting Roles in Alzheimer's Disease and Multiple Sclerosis.International journal of molecular sciences · 2025Review
- Tirzepatide: a novel therapeutic approach for Alzheimer's disease.Metabolic brain disease · 2025Review
- Leptin and Iinterlukin-6 relationship and influence of mortality in sepsis.BMC infectious diseases · 2025Article
- Cognitive function is associated with performance in time up and go test and with leptin blood levels in community-dwelling older women.Scientific reports · 2024Article
- Impact of serum leptin and adiponectin levels on brain infarcts in patients with mild cognitive impairment and Alzheimer's disease: a longitudinal analysis.Frontiers in endocrinology · 2024Article
- Air pollution accelerates the development of obesity and Alzheimer's disease: the role of leptin and inflammation - a mini-review.Frontiers in immunology · 2024Review
- Obesity as a Risk Factor for Dementia and Alzheimer's Disease: The Role of Leptin.International journal of molecular sciences · 2022Review
- Body mass index related to executive function and hippocampal subregion volume in subjective cognitive decline.Frontiers in aging neuroscience · 2022Article
- Nonobese Male Patients with Alzheimer's Disease Are Vulnerable to Decrease in Plasma Leptin.Journal of Alzheimer's disease : JAD · 2022Article
- The Other Side of Alzheimer's Disease: Influence of Metabolic Disorder Features for Novel Diagnostic Biomarkers.Journal of personalized medicine · 2020Review
- Neurocognitive Inhibitory Control Ability Performance and Correlations with Biochemical Markers in Obese Women.International journal of environmental research and public health · 2020Article
- Association Between Leptin, Cognition, and Structural Brain Measures Among "Early" Middle-Aged Adults: Results from the Framingham Heart Study Third Generation Cohort.Journal of Alzheimer's disease : JAD · 2020Article
- Consequences of Metabolic Disruption in Alzheimer's Disease Pathology.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2019Review
- U-Shaped Relationship between Serum Leptin Concentration and Cognitive Performance in Older Asian Adults.Nutrients · 2019Article
- The cause-effect relationship between bone loss and Alzheimer's disease using statistical modeling.Medical hypotheses · 2019Observational
- Treatment of Alzheimer's Disease: Trazodone, Sleep, Serotonin, Norepinephrine, and Future Directions.Journal of Alzheimer's disease : JAD · 2019Article
- Plasma Leptin Concentration and Sympathetic Nervous Activity in Older Adults With Physical Dysfunction.Journal of the Endocrine Society · 2018Article
- The Role of Leptin and Adiponectin in Obesity-Associated Cognitive Decline and Alzheimer's Disease.Frontiers in neuroscience · 2018Review
- Association between Peripheral Leptin and Adiponectin Levels and Cognitive Decline in Patients with Neurocognitive Disorders ≥65 Years.Journal of Alzheimer's disease : JAD · 2018Article
- [Effect of leptin on long-term spatial memory of rats with white matter damage in developing brain].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2017Article
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 1 country.
Funding
Abstract
Analysis of data derived from the Alzheimer's Disease Neuroimaging Initiative (ADNI) program showed plasma leptin levels in individuals with Mild Cognitive Impairment (MCI) or Alzheimer's disease (AD) to be lower than those of subjects with normal cognition (NC). Approximately 70% of both men and women with MCI have plasma leptin levels lower than the median values of NC. Additionally, half of these subjects carry at least one apolipoprotein-E4 (APOE-ε4) allele. A subgroup of participants also had cerebrospinal fluid (CSF) leptin measured. Plasma leptin typically reflected the levels of leptin in CSF in all groups (Control/MCI/AD) in both genders. The data suggest that plasma leptin deficiency provides an indication of potential CNS leptin deficiency, further supporting the exploration of plasma leptin as a diagnostic marker for MCI or AD. The important question is whether leptin deficiency plays a role in the causation of AD and/or its progression. If this is the case, individuals with early AD or MCI with low plasma leptin may benefit from leptin replacement therapy. Thus, these data indicate that trials of leptin in low leptin MCI/early-stage AD patients should be conducted to test the hypothesis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.