ArticleBMC genomics2013
Uncovering the genetic basis for early isogamete differentiation: a case study of Ectocarpus siliculosus.
Article in BMC genomics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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12 citing papers in PubMed, 43 citations in OpenAlex.
- Genome-Wide Identification and Expression Analysis ofPlants (Basel, Switzerland) · 2023Article
- Chromatin landscape associated with sexual differentiation in a UV sex determination system.Nucleic acids research · 2022Article
- Differential gene expression patterns during gametophyte development provide insights into sex differentiation in the dioicous kelp Saccharina japonica.BMC plant biology · 2021Article
- Review
- Peptimapper: proteogenomics workflow for the expert annotation of eukaryotic genomes.BMC genomics · 2019Article
- DISTAG/TBCCd1 Is Required for Basal Cell Fate Determination inThe Plant cell · 2017Article
- Phototaxis and chemotaxis of brown algal swarmers.Journal of plant research · 2017Review
- Gamete signalling underlies the evolution of mating types and their number.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2016Article
- Molecular evolution of candidate male reproductive genes in the brown algal model Ectocarpus.BMC evolutionary biology · 2016Article
- Article
- Article
- Ultrastructure and composition of the Nannochloropsis gaditana cell wall.Eukaryotic cell · 2014Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe phenomenon of sexual reproduction characterizes nearly all eukaryotes, with anisogamy being the most prevalent form of gamete discrimination. Since dimorphic gametes most likely descend from equal-sized specialized germ cells, identifying the genetic bases of the early functional diversification in isogametes can provide better understanding of the evolution of sexual dimorphism. However, despite the potential importance to the evolutionary biology field, no comprehensive survey of the transcriptome profiling in isomorphic gametes has been reported hitherto.
resultsGamete differentiation on the genomic level was investigated using Ectocarpus siliculosus, a model organism for brown algal lineage which displays an isogamous sexual reproduction cycle. Transcriptome libraries of male and female gametes were generated using Next Generation Sequencing technology (SOLiD) and analyzed to identify differentially regulated genes and pathways with potential roles in fertilization and gamete specialization. Gamete transcriptomes showed a high level of complexity with a large portion of gender specific gene expression. Our results indicate that over 4,000 of expressed genes are differentially regulated between male and female, including sequences related to cell movement, carbohydrate and lipid metabolism, signaling, transport and RNA processing.
conclusionsThis first comprehensive transcriptomic study of protist isogametes describes considerable adaptation to distinct sexual roles, suggesting that functional anisogamy precedes morphological differentiation. Several sex-biased genes and pathways with a putative role in reproduction were identified, providing the basis for more detailed investigations of the mechanisms underlying evolution of mating types and sexual dimorphism.
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