Trial reportThe international journal of behavioral nutrition and physical activity2013
Colorado stride (COSTRIDE): testing genetic and physiological moderators of response to an intervention to increase physical activity.
Trial report in The international journal of behavioral nutrition and physical activity, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01091857 (Mediators and Moderators of Exercise Behavior Change), which is not on this map. Cited by 19 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Mediators and Moderators of Exercise Behavior Change
Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Pooled it
- Pooled it
- Physical activity and differential methylation of breast cancer genes assayed from saliva: a preliminary investigation.Annals of behavioral medicine : a publication of the Society of Behavioral Medicine · 2013Trial
- Psychosocial moderators of the effect of lifestyle interventions in primary prevention of cardiovascular disease: a scoping review.BMC public health · 2025Article
- Association ofInternational journal of environmental research and public health · 2025Article
- Women's exercise identity increases after a 16-week exercise RCT and is linked to behavior maintenance at follow-up.Psychology of sport and exercise · 2021Article
- Affective response to physical activity as an intermediate phenotype.Social science & medicine (1982) · 2021Article
- Nonalcoholic steatohepatitis Fitness Intervention in Thrombosis (NASHFit): Study protocol for a randomized controlled trial of a supervised aerobic exercise program to reduce elevated clotting risk in patients with NASH.Contemporary clinical trials communications · 2020Article
- Poor Physical Fitness Performance as a Predictor of General Adiposity in Taiwanese Adults.International journal of environmental research and public health · 2020Article
- Does Preexisting Practice Modify How Video Games Recalibrate Physician Heuristics in Trauma Triage?The Journal of surgical research · 2019Article
- Constitutive PGC-1α overexpression in skeletal muscle does not protect from age-dependent decline in neurogenesis.Scientific reports · 2019Article
- Harnessing centred identity transformation to reduce executive function burden for maintenance of health behaviour change: the Maintain IT model.Health psychology review · 2018Review
- Cerebellar BDNF Promotes Exploration and Seeking for Novelty.The international journal of neuropsychopharmacology · 2018Article
- Exercise-Mediated Neurogenesis in the Hippocampus via BDNF.Frontiers in neuroscience · 2018Review
- Behavioral and Psychological Phenotyping of Physical Activity and Sedentary Behavior: Implications for Weight Management.Obesity (Silver Spring, Md.) · 2017Review
- What keeps a body moving? The brain-derived neurotrophic factor val66met polymorphism and intrinsic motivation to exercise in humans.Journal of behavioral medicine · 2014Article
- Neuroprotective effects of physical activity on the brain: a closer look at trophic factor signaling.Frontiers in cellular neuroscience · 2014Review
- Genetic Influences on Physiological and Subjective Responses to an Aerobic Exercise Session among Sedentary Adults.Journal of cancer epidemiology · 2012Article
- Characterizing Self-Monitoring Behavior and Its Association With Physical Activity and Weight Loss Maintenance.American journal of lifestyle medicineArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
backgroundThe purpose of this research was to replicate a successful intervention to increase physical activity in a different region of the country, and explore genetic and physiological moderators of intervention efficacy drawn from a transdisciplinary theoretical framework.
methodA randomized controlled trial comparing a print-based physical activity intervention (COSTRIDE) to a print-based health and wellness contact control (HW) intervention was conducted. Sedentary participants (n = 219) completed assessments at baseline and follow-up assessments at 3, 6, 9, and 12 months following the initiation of the intervention.
resultsParticipants in both conditions significantly increased exercise behavior in the first six months, and then leveled off or decreased physical activity in the second six months of the study. Those in the COSTRIDE intervention increased significantly more than those in the HW intervention, and were better able to maintain their exercise behavior. Genetic factors (BDNF, rs6265; FTO, rs8044769), but not selected physiological (body temperature, blood lactate, systolic blood pressure, plasma norepinephrine, and heart rate) or subjective (perceived pain, affect) responses to physical activity, moderated response to the intervention.
conclusionsThere are underlying genetic factors that influence response to behavioral intervention, and a better understanding of these factors has the potential to influence the development, targeting and tailoring of behavioral interventions to increase physical activity.
trial registrationClinicaltrials.gov registration: NCT01091857.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.