ArticleBMC complementary and alternative medicine2013
Kolaviron, a Garcinia biflavonoid complex ameliorates hyperglycemia-mediated hepatic injury in rats via suppression of inflammatory responses.
Article in BMC complementary and alternative medicine, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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24 citing papers in PubMed, 65 citations in OpenAlex.
- The role of Kolaviron, a bioflavonoid fromHeliyon · 2024Article
- Article
- Pharmacologically Active Phytomolecules Isolated from Traditional Antidiabetic Plants and Their Therapeutic Role for the Management of Diabetes Mellitus.Molecules (Basel, Switzerland) · 2022Review
- Effect of kolaviron on islet dynamics in diabetic rats.Saudi journal of biological sciences · 2022Article
- Kolaviron protects against nigrostriatal degeneration and gut oxidative damage in a stereotaxic rotenone model of Parkinson's disease.Psychopharmacology · 2020Article
- Kolaviron protects against cognitive deficits and cortico-hippocampal perturbations associated with maternal deprivation in rats.Anatomy & cell biology · 2020Article
- Sex Difference in Trigeminal Neuropathic Pain Response to Exercise: Role of Oxidative Stress.Pain research & management · 2020Article
- Cuprizone toxicity andHeliyon · 2019Article
- Polyphenols of marine red macroalgaHeliyon · 2019Article
- Kolaviron Protects the Prefrontal Cortex and Hippocampus against Histomorphological and Neurobehavioural Changes in Cuprizone Model of Multiple Sclerosis.The Malaysian journal of medical sciences : MJMS · 2018Article
- Article
- Medicinal plants with anti-inflammatory activities from selected countries and regions of Africa.Journal of inflammation research · 2018Review
- Centella asiatica enhances hepatic antioxidant status and regulates hepatic inflammatory cytokines in type 2 diabetic rats.Pharmaceutical biology · 2017Article
- Assessment of the Anti-Hyperglycaemic, Anti-Inflammatory and Antioxidant Activities of the Methanol Extract of Moringa Oleifera in Diabetes-Induced Nephrotoxic Male Wistar Rats.Molecules (Basel, Switzerland) · 2017Article
- The Role of Oxidative Stress, Mitochondrial Function, and Autophagy in Diabetic Polyneuropathy.Journal of diabetes research · 2017Review
- Kolaviron was protective against sodium azide (NaN3) induced oxidative stress in the prefrontal cortex.Metabolic brain disease · 2016Article
- Diabetic Polyneuropathy in Type 2 Diabetes Mellitus: Inflammation, Oxidative Stress, and Mitochondrial Function.Journal of diabetes research · 2016Review
- Effects of kolaviron on hepatic oxidative stress in streptozotocin induced diabetes.BMC complementary and alternative medicine · 2015Article
- Antioxidation and anti-inflammatory activity of Tang Bi Kang in rats with diabetic peripheral neuropathy.BMC complementary and alternative medicine · 2015Article
- Use of unripe plantain (Musa paradisiaca) in the management of diabetes and hepatic dysfunction in streptozotocin induced diabetes in rats.Interventional medicine & applied science · 2015Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundChronic inflammation plays a crucial role in hyperglycemia-induced liver injury. Kolaviron (KV), a natural biflavonoid from Garcinia kola seeds have been shown to possess anti- inflammatory properties which has not been explored in diabetes. To our knowledge, this is the first study to investigate the effect of KV on pro-inflammatory proteins in the liver of diabetic rats.
methodsDiabetes was induced by a single intraperitoneal injection of streptozotocin (STZ) (50 mg/kg) in male Wistar rats. Kolaviron (100 mg/kg) was administered orally five times a week for six weeks. The concentrations of cytokines and chemokine were measured using Bio-plex Pro™ magnetic bead-based assays (Bio-Rad Laboratories, Hercules, USA). Plasma glucose and serum biomarkers of liver dysfunction were analyzed with diagnostic kits in an automated clinical chemistry analyzer. Insulin concentration was estimated by radioimmunoassay (RIA).
resultKolaviron (100mg/kg) treatment significantly ameliorated hyperglycemia and liver dysfunction. Serum levels of hepatic marker enzymes were significantly reduced in kolaviron treated diabetic rats. Kolaviron prevented diabetes induced increase in the hepatic levels of proinflammatory cytokines; interleukin (IL)-1beta, IL-6, tumour necrosis factor (TNF-α) and monocyte chemotactic protein (MCP-1).
conclusionThe results of this study demonstrate that the hepatoprotective effects of kolaviron in diabetic rats may be partly associated with its modulating effect on inflammatory responses.
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