ArticlePediatric rheumatology online journal2013
Autoinflammatory bone disorders with special focus on chronic recurrent multifocal osteomyelitis (CRMO).
Article in Pediatric rheumatology online journal, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 91 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
91 citing papers in PubMed, 2 syntheses or guidelines pooled it, 209 citations in OpenAlex.
- Pooled it
- Consensus Treatment Plans for Chronic Nonbacterial Osteomyelitis Refractory to Nonsteroidal Antiinflammatory Drugs and/or With Active Spinal Lesions.Arthritis care & research · 2018Guideline
- How Organ Manifestations Beyond the Bone May Guide Risk Stratification and Treatment Decisions in Chronic Nonbacterial Osteomyelitis.Paediatric drugs · 2026Review
- Clinical characteristics and outcomes of paediatric chronic non-bacterial osteomyelitis: a retrospective cohort study with focus on zoledronic acid.Rheumatology (Oxford, England) · 2026Article
- Chronic Nonbacterial Osteomyelitis in Latvia from 2014 to 2025: Case Series.Medicina (Kaunas, Lithuania) · 2026Article
- Microbiome-Targeted Probiotic Strategies for the Prevention and Treatment of Osteomyelitis: A Novel Biological Approach.Probiotics and antimicrobial proteins · 2026Review
- [Inflammatory dermatosis in adult chronic non-bacterial osteomyelitis (adult CNO) from a dermatological perspective].Zeitschrift fur Rheumatologie · 2026Article
- [Chronic nonbacterial osteomyelitis/osteitis of childhood and adolescence].Zeitschrift fur Rheumatologie · 2026Review
- Evaluating the osteoclastogenic potential of peripheral blood mononuclear cells in children with chronic nonbacterial osteomyelitis.JBMR plus · 2026Article
- Ustekinumab as a novel treatment of chronic nonbacterial osteomyelitis: a case report.AME case reports · 2026Article
- Chronic nonbacterial osteomyelitis: a typical case and review.Frontiers in pediatrics · 2026Review
- Validation of the EULAR/ACR classification criteria for chronic nonbacterial osteomyelitis in a pediatric cohort.Clinical rheumatology · 2025Article
- Clinical characteristics and prognosis of patients with chronic recurrent multifocal osteomyelitis based on cluster analysis: a 6-year cohort study.Italian journal of pediatrics · 2025Article
- Impact of immunostimulation on autoinflammatory disease. CRMO case presentation and literature review: A case report.Biomedical reports · 2025Article
- The impact of sarcopenia on the progression of chronic non-bacterial osteomyelitis.Insights into imaging · 2025Article
- [Arthritis and osteomyelitis in childhood and adolescence-Bacterial and nonbacterial].Zeitschrift fur Rheumatologie · 2025Review
- Chronic Non-Bacterial Osteomyelitis (CNO) in a Tertiary Center in Southern Italy: Response to Treatment and Outcome Stratification.Children (Basel, Switzerland) · 2025Article
- A child with Chronic Nonbacterial Osteomyelitis and celiac disease: accidental association or two different aspects of the same condition?Italian journal of pediatrics · 2025Article
- Monocyte STAT1 phosphorylation and treatment response of JAK inhibitors in chronic nonbacterial osteomyelitis.Pediatric rheumatology online journal · 2025Article
- Autoinflammatory Bone Diseases.Balkan medical journal · 2025Review
31 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sterile bone inflammation is the hallmark of autoinflammatory bone disorders, including chronic nonbacterial osteomyelitis (CNO) with its most severe form chronic recurrent multifocal osteomyelitis (CRMO). Autoinflammatory osteopathies are the result of a dysregulated innate immune system, resulting in immune cell infiltration of the bone and subsequent osteoclast differentiation and activation. Interestingly, autoinflammatory bone disorders are associated with inflammation of the skin and/or the intestine. In several monogenic autoinflammatory bone disorders mutations in disease-causing genes have been reported. However, regardless of recent developments, the molecular pathogenesis of CNO/CRMO remains unclear.Here, we discuss the clinical presentation and molecular pathophysiology of human autoinflammatory osteopathies and animal models with special focus on CNO/CRMO. Treatment options in monogenic autoinflammatory bone disorders and CRMO will be illustrated.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.