ArticleF1000Research2013
A p53-like transcription factor similar to Ndt80 controls the response to nutrient stress in the filamentous fungus, Aspergillus nidulans.
Article in F1000Research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 39 citations in OpenAlex.
- N-acetylglucosamine sensing in the filamentous soil fungus Trichoderma reesei.The FEBS journal · 2025Article
- Transcription Factor SsNdt80b Maintains Optimal Expression of SsSNF1 to Modulate Growth and Pathogenicity in Sclerotinia sclerotiorum.Molecular plant pathology · 2025Article
- Development ofJournal of fungi (Basel, Switzerland) · 2024Article
- Regulation of nutrient utilization in filamentous fungi.Applied microbiology and biotechnology · 2023Review
- Transcription FactorJournal of fungi (Basel, Switzerland) · 2022Article
- Strategies Shaping the Transcription of Carbohydrate-Active Enzyme Genes inJournal of fungi (Basel, Switzerland) · 2022Article
- The Transcription FactorFrontiers in microbiology · 2022Article
- The transcription factor Ndt80 is a repressor of Candida parapsilosis virulence attributes.Virulence · 2021Article
- Understanding the Role ofJournal of fungi (Basel, Switzerland) · 2021Article
- Induction and Repression of Hydrolase Genes inFrontiers in microbiology · 2021Review
- Article
- Transcriptome Profiling Provides Insights Into Potential Antagonistic Mechanisms Involved inFrontiers in microbiology · 2020Article
- Succession of physiological stages hallmarks the transcriptomic response of the fungusBiotechnology for biofuels · 2020Article
- The role of the GATA transcription factor AreB in regulation of nitrogen and carbon metabolism in Aspergillus nidulans.FEMS microbiology letters · 2019Article
- Genetic Analysis ofmSphere · 2018Article
- Autolytic hydrolases affect sexual and asexual development of Aspergillus nidulans.Folia microbiologica · 2018Article
- Discovery of McrA, a master regulator of Aspergillus secondary metabolism.Molecular microbiology · 2017Article
- Phenotypic and Proteomic Analysis of theFrontiers in microbiology · 2017Article
- Genome sequencing and transcriptome analysis ofBiotechnology for biofuels · 2017Article
- The N-acetylglucosamine catabolic gene cluster in Trichoderma reesei is controlled by the Ndt80-like transcription factor RON1.Molecular microbiology · 2016Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The Aspergillus nidulans xprG gene encodes a putative transcriptional activator that is a member of the Ndt80 family in the p53-like superfamily of proteins. Previous studies have shown that XprG controls the production of extracellular proteases in response to starvation. We undertook transcriptional profiling to investigate whether XprG has a wider role as a global regulator of the carbon nutrient stress response. Our microarray data showed that the expression of a large number of genes, including genes involved in secondary metabolism, development, high-affinity glucose uptake and autolysis, were altered in an xprG Δ null mutant. Many of these genes are known to be regulated in response to carbon starvation. We confirmed that sterigmatocystin and penicillin production is reduced in xprG (-) mutants. The loss of fungal mass and secretion of pigments that accompanies fungal autolysis in response to nutrient depletion was accelerated in an xprG1 gain-of-function mutant and decreased or absent in an xprG (-) mutant. The results support the hypothesis that XprG plays a major role in the response to carbon limitation and that nutrient sensing may represent one of the ancestral roles for the p53-like superfamily. Disruption of the AN6015 gene, which encodes a second Ndt80-like protein, showed that it is required for sexual reproduction in A. nidulans.
Identifiers
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Registered trials
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