Evidence map›Paper›PMID 24358355›Full record

ArticlePloS one2013

Blue-violet laser modification of titania treated titanium: antibacterial and osteo-inductive effects.

Takanori Kawano, Widyasri Prananingrum, Yuichi Ishida, Takaharu Goto, Yoshihito Naito, Megumi Watanabe, Yoritoki Tomotake, Tetsuo Ichikawa

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.7field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Takanori KawanoDepartment of Oral & Maxillofacial Prosthodontics and Oral Implantology, The University of Tokushima, Institute of Health, Biosciences, Tokushima, Japan.
Widyasri PrananingrumDepartment of Oral & Maxillofacial Prosthodontics and Oral Implantology, The University of Tokushima, Institute of Health, Biosciences, Tokushima, Japan.
Yuichi IshidaDepartment of Oral & Maxillofacial Prosthodontics and Oral Implantology, The University of Tokushima, Institute of Health, Biosciences, Tokushima, Japan.
Takaharu GotoDepartment of Oral & Maxillofacial Prosthodontics and Oral Implantology, The University of Tokushima, Institute of Health, Biosciences, Tokushima, Japan.
Yoshihito NaitoDepartment of Oral & Maxillofacial Prosthodontics and Oral Implantology, The University of Tokushima, Institute of Health, Biosciences, Tokushima, Japan.
Megumi WatanabeDepartment of Oral & Maxillofacial Prosthodontics and Oral Implantology, The University of Tokushima, Institute of Health, Biosciences, Tokushima, Japan.
Yoritoki TomotakeDepartment of Oral & Maxillofacial Prosthodontics and Oral Implantology, The University of Tokushima, Institute of Health, Biosciences, Tokushima, Japan.
Tetsuo IchikawaDepartment of Oral & Maxillofacial Prosthodontics and Oral Implantology, The University of Tokushima, Institute of Health, Biosciences, Tokushima, Japan.
Tokushima University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMany studies on surface modifications of titanium have been performed in an attempt to accelerate osseointegration. Recently, anatase titanium dioxide has been found to act as a photocatalyst that expresses antibiotic properties and exhibits hydrophilicity after ultraviolet exposure. A blue-violet semiconductor laser (BV-LD) has been developed as near-ultraviolet light. The purpose of this study was to investigate the effects of exposure to this BV-LD on surface modifications of titanium with the goal of enhancing osteoconductive and antibacterial properties.

methodsThe surfaces of pure commercial titanium were polished with #800 waterproof polishing papers and were treated with anatase titania solution. Specimens were exposed using BV-LD (λ = 405 nm) or an ultraviolet light-emitting diode (UV-LED, λ = 365 nm) at 6 mW/cm(2) for 3 h. The surface modification was evaluated physically and biologically using the following parameters or tests: surface roughness, surface temperature during exposure, X-ray diffraction (XRD) analysis, contact angle, methylene blue degradation tests, adherence of Porphyromonas gingivalis, osteoblast and fibroblast proliferation, and histological examination after implantation in rats.

resultsNo significant changes were found in the surface roughness or XRD profiles after exposure. BV-LD exposure did not raise the surface temperature of titanium. The contact angle was significantly decreased, and methylene blue was significantly degraded. The number of attached P. gingivalis organisms was significantly reduced after BV-LD exposure compared to that in the no exposure group. New bone was observed around exposed specimens in the histological evaluation, and both the bone-to-specimen contact ratio and the new bone area increased significantly in exposed groups.

conclusionsThis study suggested that exposure of titanium to BV-LD can enhance the osteoconductivity of the titanium surface and induce antibacterial properties, similar to the properties observed following exposure to UV-LED.

Indexed as

Anti-Bacterial AgentsLasersOsseointegrationAnimalsBacterial AdhesionMaleMiceRatsSurface PropertiesTitaniumAnti-Bacterial AgentsTitaniumtitanium dioxide

Identifiers

PMID24358355
PMCPMC3866166
OpenAlexW1990226797

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.