ArticlePloS one2013
Clozapine prescribing in a Canadian outpatient population.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.
- Knowledge domain and trends in treatment-resistant schizophrenia (TRS) research based on CiteSpace bibliometrics analysis.Frontiers in pharmacology · 2024Pooled it
- Clozapine, relapse, and adverse events: a 10-year electronic cohort study in Canada.The British journal of psychiatry : the journal of mental science · 2024Article
- Non-prescribing of clozapine for outpatients with schizophrenia in real-world settings: The clinicians' perspectives.Schizophrenia (Heidelberg, Germany) · 2023Article
- Clozapine prescribing practice and trends in Qatar: First national observational study.Brain and behavior · 2022Observational
- A Comparison of Attitudes, Comfort, and Knowledge of Clozapine Among Two Diverse Samples of US Psychiatrists.Community mental health journal · 2022Article
- Medication Gaps and Antipsychotic Polypharmacy in Previously Hospitalized Schizophrenia Patients: An Electronic Cohort Study in Three Canadian Provinces.Frontiers in psychiatry · 2022Article
- Treatment Resistance: A Time-Based Approach for Early Identification in First Episode Psychosis.Journal of personalized medicine · 2021Article
- Switching Between Second-Generation Antipsychotics in Patients with Schizophrenia and Schizoaffective Disorder: 10-Year Cohort Study in Brazil.Frontiers in pharmacology · 2021Article
- Psychiatric pharmacist's role in overcoming barriers to clozapine use and improving management.The mental health clinician · 2019Article
- Delayed Initiation of Clozapine Continues to Be a Substantial Clinical Concern.Canadian journal of psychiatry. Revue canadienne de psychiatrie · 2018Review
- Safety of antipsychotics for the treatment of schizophrenia: a focus on the adverse effects of clozapine.Therapeutic advances in drug safety · 2018Review
- Correlates of Clozapine Use after a First Episode of Schizophrenia: Results From a Long-term Prospective Study.CNS drugs · 2016Article
- Treatment-Resistant Schizophrenia Patients Show Elevated Anterior Cingulate Cortex Glutamate Compared to Treatment-Responsive.Schizophrenia bulletin · 2016Article
- Clozapine: a review of clinical practice guidelines and prescribing trends.BMC psychiatry · 2014Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveDescription of demographics of an outpatient population of clozapine users.
methodsRetrospective chart review study of an urban population diagnosed with schizophrenia. Assessment of therapeutic histories in relation to clinical practice guidelines.
resultsSeventy-seven of the 467 patients were on clozapine therapy. Average patients' age was 39.4 ± 11.8 years) and 68% were males. The majority of patients (68%) had tried 3 or more antipsychotics before switching to clozapine, 21% had tried two and 11% had tried one. Median length of therapy prior to clozapine initiation was 8.9 years in males and 7.7 years in females.
conclusionUntil 2010, the use of clozapine was often delayed and more than 2 antipsychotic medications were tried for relatively long periods of time before patients were switched to this effective agent.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.