ArticlePloS one2013
Enhancement of anti-inflammatory activity of Aloe vera adventitious root extracts through the alteration of primary and secondary metabolites via salicylic acid elicitation.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 68 citations in OpenAlex.
- Article
- Untargeted LC-HRMS Metabolomics and Chemometrics ofPlants (Basel, Switzerland) · 2025Article
- Ultrasound-Assisted Encapsulation of Anthraquinones Extracted from Aloe-Vera Plant into Casein Micelles.Gels (Basel, Switzerland) · 2022Article
- Biotic Elicitors in Adventitious and Hairy Root Cultures: A Review from 2010 to 2022.Molecules (Basel, Switzerland) · 2022Review
- Root Cultures, a Boon for the Production of Valuable Compounds: A Comparative Review.Plants (Basel, Switzerland) · 2022Review
- Changes in secondary metabolites in soybean (Frontiers in plant science · 2022Article
- Chrysophanol: A Natural Anthraquinone with Multifaceted Biotherapeutic Potential.Biomolecules · 2019Review
- Medicinal Plants and Natural Products Used in Cataract Management.Frontiers in pharmacology · 2019Review
- Integrated Transcriptomic and Metabolomic Analysis of FiveFrontiers in plant science · 2017Article
- Evaluation of biological properties and clinical effectiveness of Aloe vera: A systematic review.Journal of traditional and complementary medicine · 2015Review
- Elicitation: a tool for enriching the bioactive composition of foods.Molecules (Basel, Switzerland) · 2014Review
- Chrysophanol inhibits NALP3 inflammasome activation and ameliorates cerebral ischemia/reperfusion in mice.Mediators of inflammation · 2014Article
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Authors and funding
12 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Aloe vera (Asphodeloideae) is a medicinal plant in which useful secondary metabolites are plentiful. Among the representative secondary metabolites of Aloe vera are the anthraquinones including aloe emodin and chrysophanol, which are tricyclic aromatic quinones synthesized via a plant-specific type III polyketide biosynthesis pathway. However, it is not yet clear which cellular responses can induce the pathway, leading to production of tricyclic aromatic quinones. In this study, we examined the effect of endogenous elicitors on the type III polyketide biosynthesis pathway and identified the metabolic changes induced in elicitor-treated Aloe vera adventitious roots. Salicylic acid, methyl jasmonate, and ethephon were used to treat Aloe vera adventitious roots cultured on MS liquid media with 0.3 mg/L IBA for 35 days. Aloe emodin and chrysophanol were remarkably increased by the SA treatment, more than 10-11 and 5-13 fold as compared with untreated control, respectively. Ultra-performance liquid chromatography-electrospray ionization mass spectrometry analysis identified a total of 37 SA-induced compounds, including aloe emodin and chrysophanol, and 3 of the compounds were tentatively identified as tricyclic aromatic quinones. Transcript accumulation analysis of polyketide synthase genes and gas chromatography mass spectrometry showed that these secondary metabolic changes resulted from increased expression of octaketide synthase genes and decreases in malonyl-CoA, which is the precursor for the tricyclic aromatic quinone biosynthesis pathway. In addition, anti-inflammatory activity was enhanced in extracts of SA-treated adventitious roots. Our results suggest that SA has an important role in activation of the plant specific-type III polyketide biosynthetic pathway, and therefore that the efficacy of Aloe vera as medicinal agent can be improved through SA treatment.
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