ArticlePloS one2013
The V protein of canine distemper virus is required for virus replication in human epithelial cells.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 22 citations in OpenAlex.
- Metagenomics-enabled reverse-genetics assembly and characterization of myotis bat morbillivirus.Nature microbiology · 2023Article
- Detection of Selected Canine Viruses in Nigerian Free-Ranging Dogs Traded for Meat Consumption.Animals : an open access journal from MDPI · 2023Article
- C Proteins: Controllers of Orderly Paramyxovirus Replication and of the Innate Immune Response.Viruses · 2022Review
- Zoonotic potential of a novel bat morbillivirus.Research square · 2021Article
- Canine Morbillivirus from Colombian Lineage Exhibits In Silico and In Vitro Potential to Infect Human Cells.Pathogens (Basel, Switzerland) · 2021Article
- Systematic Review of Important Viral Diseases in Africa in Light of the 'One Health' Concept.Pathogens (Basel, Switzerland) · 2020Article
- Phylogenomic Analysis of Two Co-Circulating Canine Distemper Virus Lineages in Colombia.Pathogens (Basel, Switzerland) · 2019Article
- Review
- Tropism and molecular pathogenesis of canine distemper virus.Virology journal · 2019Review
- Origin of Canine Distemper Virus: Consolidating Evidence to Understand Potential Zoonoses.Frontiers in microbiology · 2019Article
- The canine MHC class Ia allele DLA-88*508:01 presents diverse self- and canine distemper virus-origin peptides of varying length that have a conserved binding motif.Veterinary immunology and immunopathology · 2018Article
- Article
- Peste des petits ruminants virus infection of small ruminants: a comprehensive review.Viruses · 2014Review
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Canine distemper virus (CDV) becomes able to use human receptors through a single amino acid substitution in the H protein. In addition, CDV strains possessing an intact C protein replicate well in human epithelial H358 cells. The present study showed that CDV strain 007Lm, which was isolated from lymph node tissue of a dog with distemper, failed to replicate in H358 cells, although it possessed an intact C protein. Sequence analyses suggested that a cysteine-to-tyrosine substitution at position 267 of the V protein caused this growth defect. Analyses using H358 cells constitutively expressing the CDV V protein showed that the V protein with a cysteine, but not that with a tyrosine, at this position effectively blocked the interferon-stimulated signal transduction pathway, and supported virus replication of 007Lm in H358 cells. Thus, the V protein as well as the C protein appears to be functional and essential for CDV replication in human epithelial cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.