ArticleThe open cardiovascular medicine journal2013
Incidence and pattern of thyroid dysfunction in patients on chronic amiodarone therapy: experience at a tertiary care centre in oman.
Article in The open cardiovascular medicine journal, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed, 13 citations in OpenAlex.
- Life-threatening amiodarone-induced thyrotoxicosis - Personalized approach to radical treatment.Heliyon · 2024Article
- [Iodine-induced thyroid dysfunction].Medizinische Klinik, Intensivmedizin und Notfallmedizin · 2021Review
- Thyroid Disorders in Homozygous β-Thalassemia: Current Knowledge, Emerging Issues and Open Problems.Mediterranean journal of hematology and infectious diseases · 2019Review
- Thyroidectomy for Amiodarone-Induced Thyrotoxicosis: Mayo Clinic Experience.Journal of the Endocrine Society · 2018Article
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8 authors at 1 institution in 1 country.
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Abstract
objectiveTo determine the incidence and pattern of thyroid dysfunction (TD) in patients on chronic amiodarone therapy.
methodsA retrospective study which evaluated 59 patients who had received amiodarone therapy regularly for at least 12 months from a period of 3 years from October 2007 to October 2010. The patients were followed-up at the cardiac clinic at Sultan Qaboos University Hospital, Muscat, Oman.
resultsThe mean age of the cohort was 63 ± 13 years ranging from 27 to 98 years. Fifty-one percent (n = 30) of the patients were female. There were 11 (19%) cases of thyroid dysfunction (TD). Seven (12%) patients were hypothyroid, 3 (5%) had hyperthyroidism and 1 (2%) patient had sub-clinical hypothyroidism; no cases of sub-clinical hyperthyroidism were noted. Female gender and presence of anti-thyroid peroxidase antibodies were significantly associated with amiodarone-induced hypothyroidism (p = 0.001) while age, amiodarone dose and duration of therapy were not correlated with the development of TD (all p-values > 0.05).
conclusionAmiodarone-induced thyroid dysfunction is prevalent. Hypothyroidism was more frequent and seen more in female patients and those who had positive anti-thyroid peroxidase antibodies. Initial screening and periodic monitoring of thyroid function is mandatory for all patients on amiodarone therapy.
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