Evidence map›Paper›PMID 24358054›Full record

ArticleNature photonics2013

Wide-field optical detection of nanoparticles using on-chip microscopy and self-assembled nanolenses.

Onur Mudanyali, Euan McLeod, Wei Luo, Alon Greenbaum, Ahmet F Coskun, Yves Hennequin, Cédric P Allier, Aydogan Ozcan

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature photonics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

45 citing papers in PubMed.

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  9. Computational Optics for Point-of-Care Breast Cancer Profiling.Methods in molecular biology (Clifton, N.J.) · 2022
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Onur MudanyaliElectrical Engineering Department, University of California, Los Angeles, California 90095, USA ; Bioengineering Department, University of California, Los Angeles, California 90095, USA.
Euan McLeodElectrical Engineering Department, University of California, Los Angeles, California 90095, USA ; Bioengineering Department, University of California, Los Angeles, California 90095, USA.
Wei LuoElectrical Engineering Department, University of California, Los Angeles, California 90095, USA ; Bioengineering Department, University of California, Los Angeles, California 90095, USA.
Alon GreenbaumElectrical Engineering Department, University of California, Los Angeles, California 90095, USA ; Bioengineering Department, University of California, Los Angeles, California 90095, USA.
Ahmet F CoskunElectrical Engineering Department, University of California, Los Angeles, California 90095, USA ; Bioengineering Department, University of California, Los Angeles, California 90095, USA.
Yves HennequinCEA, LETI, MINATEC, 17 rue des Martyrs, 38054 Grenoble cedex 9, France.
Cédric P AllierCEA, LETI, MINATEC, 17 rue des Martyrs, 38054 Grenoble cedex 9, France.
Aydogan OzcanElectrical Engineering Department, University of California, Los Angeles, California 90095, USA ; Bioengineering Department, University of California, Los Angeles, California 90095, USA ; California NanoSystems Institute, University of California, Los Angeles, California 90095, USA ; Department of Surgery, David Geffen School of Medicine, University of California, Los Angeles, California 90095, USA.

Funding

Towards Mega-Throughput, Label-free Genomics and Proteomics: Revolutionizing MicrDP2OD006427 · OD · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI OZCAN, AYDOGAN · 2009 to 2009
$2.3M
NIH HHS DP2 OD006427
6 · The paper itself

Abstract

The direct observation of nanoscale objects is a challenging task for optical microscopy because the scattering from an individual nanoparticle is typically weak at optical wavelengths. Electron microscopy therefore remains one of the gold standard visualization methods for nanoparticles, despite its high cost, limited throughput and restricted field-of-view. Here, we describe a high-throughput, on-chip detection scheme that uses biocompatible wetting films to self-assemble aspheric liquid nanolenses around individual nanoparticles to enhance the contrast between the scattered and background light. We model the effect of the nanolens as a spatial phase mask centred on the particle and show that the holographic diffraction pattern of this effective phase mask allows detection of sub-100 nm particles across a large field-of-view of >20 mm

Identifiers

PMID24358054
PMCPMC3866034

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.