ArticleSoft matter2013
Deformation of a Two-domain Lipid Bilayer due to Asymmetric Insertion of Lipid-modified Ras Peptides.
Article in Soft matter, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
15 citing papers in PubMed.
- RAS GTPases and Interleaflet Coupling in the Plasma Membrane.Cold Spring Harbor perspectives in biology · 2023Review
- Remodeling of the Plasma Membrane by Surface-Bound Protein Monomers and Oligomers: The Critical Role of Intrinsically Disordered Regions.The Journal of membrane biology · 2022Review
- Molecular Dynamics Simulation of Lipid-Modified Signaling Proteins.Methods in molecular biology (Clifton, N.J.) · 2021Article
- RAS Nanoclusters Selectively Sort Distinct Lipid Headgroups and Acyl Chains.Frontiers in molecular biosciences · 2021Review
- Membrane curvature sensing of the lipid-anchored K-Ras small GTPase.Life science alliance · 2019Article
- Characterization of Lipid-Protein Interactions and Lipid-Mediated Modulation of Membrane Protein Function through Molecular Simulation.Chemical reviews · 2019Review
- Interplay between Membrane Curvature and Cholesterol: Role of Palmitoylated Caveolin-1.Biophysical journal · 2019Article
- Ras and the Plasma Membrane: A Complicated Relationship.Cold Spring Harbor perspectives in medicine · 2018Review
- Deciphering lipid codes: K-Ras as a paradigm.Traffic (Copenhagen, Denmark) · 2018Review
- Membrane Curvature and Lipid Composition Synergize To Regulate N-Ras Anchor Recruitment.Biophysical journal · 2017Article
- Reversible Effects of Peptide Concentration and Lipid Composition on H-Ras Lipid Anchor Clustering.Biophysical journal · 2015Article
- Oligomerization and nanocluster organization render specificity.Biological reviews of the Cambridge Philosophical Society · 2015Review
- Modulation of a small two-domain lipid vesicle by linactants.The journal of physical chemistry. B · 2014Article
- Membrane Remodeling by Surface-Bound Protein Aggregates: Insights from Coarse-Grained Molecular Dynamics Simulation.The journal of physical chemistry letters · 2014Article
- Overview of simulation studies on the enzymatic activity and conformational dynamics of the GTPase Ras.Molecular simulationArticle
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Ras proteins are attached to the inner leaflet of the plasma membrane via a lipid-modified anchor. Membrane-bound Ras proteins laterally segregate into nanoscale signaling platforms called nanoclusters. It has been shown that the membrane domain preference of Ras nanoclusters varies with the nature of lipidation but their effect on the membrane has not been well understood. To investigate the effect of Ras insertion on membrane structure, we carried out numerous coarse-grained molecular dynamics (CGMD) simulations on a two-domain DPPC/DLiPC/cholesterol lipid bilayer in which different number and type of H-ras peptides were attached on one side. We have shown previously that this lipid mixture forms co-existing liquid-ordered/liquid-disordered (L
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