ArticleJournal of cell science2014
Mitoneet mediates TNFα-induced necroptosis promoted by exposure to fructose and ethanol.
Article in Journal of cell science, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 11 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 20 citations in OpenAlex.
- Faecalibaculum rodentium Alleviates Ionizing Radiation-Induced Damage in Mice by Improving Intestinal Integrity and Hematopoiesis via Its Metabolite Butyrate.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Isoliquiritigenin Induces Mitochondrial Dysfunction and Apoptosis by Inhibiting mitoNEET in a Reactive Oxygen Species-Dependent Manner in A375 Human Melanoma Cells.Oxidative medicine and cellular longevity · 2019Article
- Insulin Production and Resistance in Different Models of Diet-Induced Obesity and Metabolic Syndrome.International journal of molecular sciences · 2017Article
- MicroRNA-127 targeting of mitoNEET inhibits neurite outgrowth, induces cell apoptosis and contributes to physiological dysfunction after spinal cord transection.Scientific reports · 2016Article
- A novel heat shock protein alpha 8 (Hspa8) molecular network mediating responses to stress- and ethanol-related behaviors.Neurogenetics · 2016Article
- Mitochondrial Stat3, the Need for Design Thinking.International journal of biological sciences · 2016Review
- Reactive oxygen species regulate Smac mimetic/TNFα-induced necroptotic signaling and cell death.Oncogene · 2015Article
- Receptor interacting protein 3-induced RGC-5 cell necroptosis following oxygen glucose deprivation.BMC neuroscience · 2015Article
- Reduction of mitochondrial protein mitoNEET [2Fe-2S] clusters by human glutathione reductase.Free radical biology & medicine · 2015Article
- The effect and underlying mechanism of Timosaponin B-II on RGC-5 necroptosis induced by hydrogen peroxide.BMC complementary and alternative medicine · 2014Article
- Article
Corrections and comments
- Expression of concern · 2016-02-15Concerns/Issues about Image · Investigation by Company/Institution · Investigation by Journal/Publisher · Objections by Third Party · · This EoC is upgraded by PMID: 27369364, citing Misconduct by John G Pastorino;
- Retraction · 2016-07-01Duplication of/in Image · Falsification/Fabrication of Data · Investigation by Company/Institution · Investigation by Journal/Publisher · Investigation by ORI · Manipulation of Images · Misconduct - Official Investigation(s) and/or Finding(s) · Misconduct by Author · Objections by Third Party · Upgrade/Update of Prior Notice(s) · · Misconduct by John G Pastorino; Expression of Concern at PMID: 26905969;
- Commented on by
- Commented on by
- Expression of concern
- Retracted
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Fructose and ethanol are metabolized principally in the liver and are both known to contribute to the development of hepatic steatosis that can progress to hepatic steatohepatitis. The present study indentifies a synergistic interaction between fructose and ethanol in promoting hepatocyte sensitivity to TNFα-induced necroptosis. Concurrent exposure to fructose and ethanol induces the overexpression of the CDGSH iron-sulfur domain-containing protein 1 (CISD1 or mitoneet), which is localized to the outer mitochondrial membrane. The increased expression of mitoneet primes the hepatocyte for TNFα-induced cytotoxicity. Treatment with TNFα induces the translocation of a Stat3-Grim-19 complex to the mitochondria, which binds to mitoneet and promotes the rapid release of its 2Fe-2S cluster, causing an accumulation of mitochondrial iron. The dramatic increase of mitochondrial iron provokes a surge in formation of reactive oxygen species, resulting in mitochondrial injury and cell death. Additionally, mitoneet is constitutively expressed at high levels in L929 fibrosarcoma cells and is required for L929 cells to undergo TNFα-induced necroptosis in the presence of caspase inhibition, indicating the importance of mitoneet to the necroptotic form of cell death.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.