ArticleProceedings of the National Academy of Sciences of the United States of America2014
Mechanisms underlying subunit independence in pyramidal neuron dendrites.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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28 citing papers in PubMed, 56 citations in OpenAlex.
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- What makes human cortical pyramidal neurons functionally complex.bioRxiv : the preprint server for biology · 2024Article
- Probing multiplexed basal dendritic computations using two-photon 3D holographic uncaging.Cell reports · 2024Article
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- Network-neuron interactions underlying sensory responses of layer 5 pyramidal tract neurons in barrel cortex.PLoS computational biology · 2024Article
- The impact of Hodgkin-Huxley models on dendritic research.The Journal of physiology · 2023Review
- Theoretical considerations and supporting evidence for the primary role of source geometry on field potential amplitude and spatial extent.Frontiers in cellular neuroscience · 2023Review
- A multilayer-multiplexer network processing scheme based on the dendritic integration in a single neuron.AIMS neuroscience · 2022Article
- Data-driven reduction of dendritic morphologies with preserved dendro-somatic responses.eLife · 2021Article
- Illuminating dendritic function with computational models.Nature reviews. Neuroscience · 2020Review
- Type-specific dendritic integration in mouse retinal ganglion cells.Nature communications · 2020Article
- A Model of Memory Linking Time to Space.Frontiers in computational neuroscience · 2020Article
- Article
- Tuft dendrites of pyramidal neurons operate as feedback-modulated functional subunits.PLoS computational biology · 2019Article
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- A Neurodynamic Model of Feature-Based Spatial Selection.Frontiers in psychology · 2018Article
- Active dendritic integration as a mechanism for robust and precise grid cell firing.Nature neuroscience · 2017Article
- Higher-Order Synaptic Interactions Coordinate Dynamics in Recurrent Networks.PLoS computational biology · 2016Article
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2 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Pyramidal neuron (PN) dendrites compartmentalize voltage signals and can generate local spikes, which has led to the proposal that their dendrites act as independent computational subunits within a multilayered processing scheme. However, when a PN is strongly activated, back-propagating action potentials (bAPs) sweeping outward from the soma synchronize dendritic membrane potentials many times per second. How PN dendrites maintain the independence of their voltage-dependent computations, despite these repeated voltage resets, remains unknown. Using a detailed compartmental model of a layer 5 PN, and an improved method for quantifying subunit independence that incorporates a more accurate model of dendritic integration, we first established that the output of each dendrite can be almost perfectly predicted by the intensity and spatial configuration of its own synaptic inputs, and is nearly invariant to the rate of bAP-mediated "cross-talk" from other dendrites over a 100-fold range. Then, through an analysis of conductance, voltage, and current waveforms within the model cell, we identify three biophysical mechanisms that together help make independent dendritic computation possible in a firing neuron, suggesting that a major subtype of neocortical neuron has been optimized for layered, compartmentalized processing under in-vivo-like spiking conditions.
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