ArticleThe EMBO journal2014
The Arabidopsis PEPR pathway couples local and systemic plant immunity.
Article in The EMBO journal, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers.
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Who cites it
55 citing papers in PubMed.
- Dissecting root-specific non-conventional effector-triggered immunity and its role in defense and shifting the microbiome.Nature communications · 2026Article
- PEPR1 Mediates SsNLP1-Triggered Immunity AgainstInternational journal of molecular sciences · 2026Article
- Selected cell wall-associated components in plant defense responses against microbial pathogens.Frontiers in plant science · 2026Review
- The molecular framework balancing growth and defense in response to plant elicitor peptide-induced signals in Arabidopsis.The Plant cell · 2024Article
- The PpPep2-Triggered PTI-like Response in Peach Trees Is Mediated by miRNAs.International journal of molecular sciences · 2024Article
- An emerging connected view: Phytocytokines in regulating stomatal, apoplastic, and vascular immunity.Current opinion in plant biology · 2024Review
- Pull the fuzes: Processing protein precursors to generate apoplastic danger signals for triggering plant immunity.Plant communications · 2024Review
- Plant NLR immunity activation and execution: a biochemical perspective.Open biology · 2024Review
- Differential expression of the genes encoding immune system components in response to3 Biotech · 2024Article
- N-hydroxypipecolic acid triggers systemic acquired resistance through extracellular NAD(P).Nature communications · 2023Article
- Plant extracellular self-DNA inhibits growth and induces immunity via the jasmonate signaling pathway.Plant physiology · 2023Article
- Plant elicitor peptide 1 fortifies root cell walls and triggers a systemic root-to-shoot immune signaling inPlant signaling & behavior · 2022Article
- Article
- BoPEP4, a C-Terminally Encoded Plant Elicitor Peptide from Broccoli, Plays a Role in Salinity Stress Tolerance.International journal of molecular sciences · 2022Article
- Root-specific CLE3 expression is required for WRKY33 activation in Arabidopsis shoots.Plant molecular biology · 2022Article
- A sugarcane smut fungus effector simulates the host endogenous elicitor peptide to suppress plant immunity.The New phytologist · 2022Article
- CRISPR/Cas9-MediatedInternational journal of molecular sciences · 2021Article
- A primary cell wall cellulose-dependent defense mechanism against vascular pathogens revealed by time-resolved dual transcriptomics.BMC biology · 2021Article
- Advances and perspectives in discovery and functional analysis of small secreted proteins in plants.Horticulture research · 2021Review
- Prunus persica plant endogenous peptides PpPep1 and PpPep2 cause PTI-like transcriptome reprogramming in peach and enhance resistance to Xanthomonas arboricola pv. pruni.BMC genomics · 2021Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recognition of microbial challenges leads to enhanced immunity at both the local and systemic levels. In Arabidopsis, EFR and PEPR1/PEPR2 act as the receptor for the bacterial elongation factor EF-Tu (elf18 epitope) and for the endogenous PROPEP-derived Pep epitopes, respectively. The PEPR pathway has been described to mediate defence signalling following microbial recognition. Here we show that PROPEP2/PROPEP3 induction upon pathogen challenges is robust against jasmonate, salicylate, or ethylene dysfunction. Comparative transcriptome profiling between Pep2- and elf18-treated plants points to co-activation of otherwise antagonistic jasmonate- and salicylate-mediated immune branches as a key output of PEPR signalling. Accordingly, as well as basal defences against hemibiotrophic pathogens, systemic immunity is reduced in pepr1 pepr2 plants. Remarkably, PROPEP2/PROPEP3 induction is essentially restricted to the pathogen challenge sites during pathogen-induced systemic immunity. Localized Pep application activates genetically separable jasmonate and salicylate branches in systemic leaves without significant PROPEP2/PROPEP3 induction. Our results suggest that local PEPR activation provides a critical step in connecting local to systemic immunity by reinforcing separate defence signalling pathways.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.