ArticleDrugs & aging2014
Medication for Alzheimer's disease and associated fall hazard: a retrospective cohort study from the Alzheimer's Disease Neuroimaging Initiative.
Article in Drugs & aging, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Alzheimer's Disease is an Important Risk Factor of Fractures: a Meta-analysis of Cohort Studies.Molecular neurobiology · 2017Pooled it
- Reply to: "Assessment of heart rate variability and occurrence of falls in Alzheimer's disease: an exploratory study".Arquivos de neuro-psiquiatria · 2026Article
- Assessment of heart rate variability and occurrence of falls in Alzheimer's disease: an exploratory study.Arquivos de neuro-psiquiatria · 2026Article
- Association between falls and dementia risk: Evidence from three cohort studies.Journal of translational internal medicine · 2025Article
- Integrating Social Determinants of Health in a Multi-Modal Deep Clustering Survival Model for Injury-Risk in Alzheimer's and Related Dementia Patients.Proceedings of machine learning research · 2025Article
- Cholinesterase Inhibitor Initiation Does Not Increase the Risk of Fall-Related Injury in Older Adults Treated With Beta-Blockers: A Self-Controlled Case Series Design.The journals of gerontology. Series A, Biological sciences and medical sciences · 2024Article
- Falls and Alzheimer Disease.Advances in geriatric medicine and research · 2024Article
- Differences in fall-related characteristics across cognitive disorders.Frontiers in aging neuroscience · 2023Review
- Use of antipsychotic drugs and cholinesterase inhibitors and risk of falls and fractures: self-controlled case series.BMJ (Clinical research ed.) · 2021Observational
- The Efficacy of Fall Hazards Identification on Fall Outcomes: A Systematic Review With Meta-analysis.Archives of rehabilitation research and clinical translation · 2020Review
- Falls Risk and Alzheimer Disease: A Patient Guide.Archives of physical medicine and rehabilitation · 2020Article
- The risk of fall accidents for home dwellers with dementia-A register- and population-based case-control study.Alzheimer's & dementia (Amsterdam, Netherlands) · 2018Article
- The correlation of specific medication groups and falls risk in elderly. A medication logbook survey.Journal of frailty, sarcopenia and falls · 2017Article
- Recent publications from the Alzheimer's Disease Neuroimaging Initiative: Reviewing progress toward improved AD clinical trials.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2017Review
- 2014 Update of the Alzheimer's Disease Neuroimaging Initiative: A review of papers published since its inception.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2015Review
- Effects of drug pharmacokinetic/pharmacodynamic properties, characteristics of medication use, and relevant pharmacological interventions on fall risk in elderly patients.Therapeutics and clinical risk management · 2014Review
- Adapted Home-Based Exercises in Dementia: An Exploratory Pre-post Pilot and Feasibility Study.American journal of Alzheimer's disease and other dementiasArticle
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
backgroundFalls are common in the elderly, especially in those with cognitive impairment. The elderly are often treated with several medications, which may have both beneficial and deleterious effects. The use and type of medication in Alzheimer's disease (AD) patients and association with falls is limited.
objectiveWe examined the association between falls and medication use in the Alzheimer's Disease Neuroimaging Initiative (ADNI).
methodsDiagnosis, demographics, medication use, apolipoprotein E4 allele status and functional activity level at baseline were gathered for 810 participants enrolled in the ADNI, including healthy controls and subjects with mild cognitive impairment or Alzheimer's. Reports detailing adverse event falls were tabulated. Baseline characteristics were compared between subjects with and without one or more falls. Cox proportional hazards models were conducted to evaluate the association between subject characteristics and hazard of the first fall.
resultsAge (p < 0.0001), Functional Activities Questionnaire (p = 0.035), Beers List (p = 0.0477) and medications for treating cognitive symptoms of Alzheimer's (p = 0.0019) were associated with hazard of fall in the univariate model. In the final multivariate model, after adjusting for covariates, Alzheimer's medication use (p = 0.0005) was associated with hazard of fall. Medication was changed by the clinician after an adverse fall event in 9% of the falls. About 7% of the falls were reported as serious adverse events and 6% were reported to be severe.
conclusionWe found a significant association between the use of symptomatic medication treating cognitive symptoms in AD and hazard of fall after adjusting for age and Beers List medication use. Additional pharmacovigilance of the association between falls and Alzheimer's medication use is warranted.
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