ArticleSkeletal radiology2014
Subchondral insufficiency fracture of the femoral head in a patient with alkaptonuria.
Article in Skeletal radiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
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Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.
- Diagnosis of Inherited Metabolic Disease in Older Patients: A Systematic Literature Review.Journal of inherited metabolic disease · 2025Pooled it
- Microdamage accumulation in the femoral head and its association with subchondral insufficiency fractures: A retrospective study.Bone reports · 2026Article
- Osteoporosis, Osteoarthritis, and Subchondral Insufficiency Fracture: Recent Insights.Biomedicines · 2024Review
- Bilateral rapidly destructive coxopathy in rheumatoid arthritis.Reumatologia · 2024Review
- Current Research on Subchondral Insufficiency Fracture of the Femoral Head.Clinics in orthopedic surgery · 2022Review
- Alkaptonuria with rapidly destructive arthropathy of the hip: A case report and literature review.Acta orthopaedica et traumatologica turcica · 2021Review
- Frequency, diagnosis, pathogenesis and management of osteoporosis in alkaptonuria: data analysis from the UK National Alkaptonuria Centre.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2021Article
- Subchondral insufficiency fractures of the femoral head: systematic review of diagnosis, treatment and outcomes.Journal of hip preservation surgery · 2020Article
- The Distribution of Ochronosis in Osteoarthritic Articular Cartilage in a Knee.HSS journal : the musculoskeletal journal of Hospital for Special Surgery · 2016Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We report a patient with alkaptonuria accompanied by bilateral rapidly destructive arthrosis of the hip. The destruction of the left hip joint with its severe functional impairment necessitated total hip arthroplasty (THA). The outcome was satisfactory. Both magnetic resonance imaging (MRI) and pathologic findings were compatible with a subchondral insufficiency fracture. A year and half later, during a follow-up visit, the patient complained of right coxalgia. Radiography showed that the right femoral head had already disappeared, requiring THA of the right hip. Although there have been a few reports of rapid destructive hip osteoarthritis associated with ochronotic arthropathy, the pathogenesis of the destructive change is not clear. Subchondral insufficiency fracture was diagnosed on MR imaging and pathologically confirmed in our patient with alkaptonuria, suggesting that subchondral insufficiency fracture is one of the causes of ochronotic hip destruction.
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