ReviewActa neuropathologica2014
Cognitive and social lifestyle: links with neuropathology and cognition in late life.
Review in Acta neuropathologica, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 69 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
69 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Computerised cognitive training for 12 or more weeks for maintaining cognitive function in cognitively healthy people in late life.The Cochrane database of systematic reviews · 2020Pooled it
- Computerised cognitive training for maintaining cognitive function in cognitively healthy people in late life.The Cochrane database of systematic reviews · 2019Pooled it
- Computerised cognitive training for maintaining cognitive function in cognitively healthy people in midlife.The Cochrane database of systematic reviews · 2019Pooled it
- Effectiveness of interventions to prevent pre-frailty and frailty progression in older adults: a systematic review.JBI database of systematic reviews and implementation reports · 2018Pooled it
- Attributable risk of Alzheimer's dementia attributed to age-related neuropathologies.Annals of neurology · 2019Trial
- Patterns of cognitive function in middle-aged and elderly Chinese adults-findings from the EMCOA study.Alzheimer's research & therapy · 2018Trial
- Trial
- Impact of the Baltimore Experience Corps Trial on cortical and hippocampal volumes.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2015Trial
- Cognitive performance and active lifestyle in community-dwelling older adults.Dementia & neuropsychologia · 2026Article
- Factors associated with age at tau pathology onset and time from tau onset to dementia in Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Meaning in life and neurobiomarkers of brain health in the UK Biobank.Journal of Alzheimer's disease : JAD · 2025Article
- Buffering brain aging: education moderates language impairment in Parkinson's disease.Frontiers in cellular neuroscience · 2025Article
- Cognitive and physical activities are associated with cognitive resilience in a memory clinic cohort.Brain communications · 2025Article
- Loneliness, cerebrovascular and Alzheimer's disease pathology, and cognition.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Uncovering the relationship between trace element exposure, cognitive function, and dietary inflammation index in elderly americans from the National Health and Nutrition Examination Survey 2011-2014.BMC public health · 2024Article
- Relation of Cognitive Reserve Indicator to Heart Disease and Cardiac Structure and Function: A Large Community-Based Longitudinal Study.Journal of the American Heart Association · 2024Article
- Lost in space(s): Multimodal neuroimaging of disorientation along the Alzheimer's disease continuum.Human brain mapping · 2024Article
- Loneliness Predicts Progression of Frailty in Married and Widowed, but Not Unmarried Community Dwelling Older Adults.The Journal of frailty & aging · 2024Article
- Sex differences in the mediating role of chronic inflammation on the association between social isolation and cognitive functioning among older adults in the United States.Psychoneuroendocrinology · 2023Article
- Dynamic functional connectivity patterns associated with dementia risk.Alzheimer's research & therapy · 2022Article
9 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
Many studies report an association of cognitive and social experiential factors and related traits with dementia risk. Further, many clinical-pathologic studies find a poor correspondence between levels of neuropathology and the presence of dementia and level of cognitive impairment. The poor correspondence suggests that other factors contribute to the maintenance or loss of cognitive function, with factors associated with the maintenance of function referred to as neural or cognitive reserve. This has led investigators to examine the associations of cognitive and social experiential factors with neuropathology as a first step in disentangling the complex associations between these experiential risk factors, neuropathology, and cognitive impairment. Despite the consistent associations of a range of cognitive and social lifestyle factors with cognitive decline and dementia risk, the extant clinical-pathologic data find only a single factor from one cohort, linguistic ability, related to AD pathology. Other factors, including education, harm avoidance, and emotional neglect, are associated with cerebrovascular disease. Overall, the associations are weak. Some factors, such as education, social networks, and purpose in life, modify the relation of neuropathology to cognition. Finally, some factors such as cognitive activity appear to bypass known pathologies altogether suggesting a more direct association with biologic indices that promote person-specific differences in reserve and resilience. Future work will first need to replicate findings across more studies to ensure the veracity of the existing data. Second, effort is needed to identify the molecular substrates of neural reserve as potential mediators of the association of lifestyle factors with cognition.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.