ArticleEndocrine pathology2014
Papillary thyroid carcinoma with predominant spindle cell component: report of two rare cases and discussion on the differential diagnosis with other spindled thyroid neoplasm.
Article in Endocrine pathology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 13 citations in OpenAlex.
- An unusual spindle cell variant of papillary thyroid carcinoma with KIF5B::MET fusion: report of a case.Virchows Archiv : an international journal of pathology · 2026Article
- Spindle lesions in the thyroid: a cytological and histological review.Virchows Archiv : an international journal of pathology · 2025Review
- Papillary Thyroid Carcinoma with Spindle Cell Metaplasia: A Rare Encounter.Diagnostics (Basel, Switzerland) · 2022Article
- Primary solitary fibrous tumor of the thyroid gland: A review starting from a case report.Archive of clinical cases · 2021Review
- Thyroid Gland Solitary Fibrous Tumor: Report of 3 Cases and a Comprehensive Review of the Literature.Head and neck pathology · 2019Review
- Article
- Foci of spindle cell proliferation in multinodular goiter of thyroid: epithelial-mesenchymal transformation or embryonic remnants?International journal of clinical and experimental pathology · 2018Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Spindle cell transformation or metaplasia has been so far demonstrated in the context of both benign and malignant conditions. Spindle cell lesions of the thyroid gland of either primary or secondary origin to metastatic disease represent rare entities. We describe two patients with papillary thyroid carcinoma (PTC) showing spindle cell metaplasia, submitted to thyroidectomy due to euthyroid bilateral nodular thyroid disease. Cytological examination of fine-needle aspiration biopsy performed in the dominant nodules was consistent with follicular neoplasm in one case and with a hyperplastic/adenomatous nodule in the other patient. Histological examination disclosed unencapsulated follicular variant of PTC with spindle cell metaplasia in either cases. Both patients are doing well without clinical or laboratory evidence of PTC recurrence at 3- and 1-year follow-up, respectively. We present the clinical, pathological, and immunohistochemical aspects of these unusual cases and thoroughly discuss the differential diagnosis with other spindle cell lesions of the thyroid gland.
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