Evidence map›Paper›PMID 24356458›Full record

ArticleJournal of clinical gastroenterology2015

Self-efficacy and adherence to antiviral treatment for chronic hepatitis C.

Jason E Bonner, Denise A Esserman, Carol E Golin, Donna M Evon

Abstract read
In one paragraph

Article in Journal of clinical gastroenterology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Jason E BonnerDepartments of *Medicine, Division of Gastroenterology and Hepatology †Medicine ‡Biostatistics, Gillings School of Public Health §Division of General Medicine and Clinical Epidemiology, University of North Carolina, Chapel Hill, NC.
Denise A Esserman
Carol E Golin
Donna M Evon

Funding

Virology, Immunology, and Microbiology CoreP30AI050410 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI DAVID M. MARGOLIS · 2001 to 2026
$76.9M
UNC CLINICAL AND TRANSLATIONAL SCIENCE AWARD: BPCAUL1RR025747 · NCRR · UNIV OF NORTH CAROLINA CHAPEL HILL · PI RUNGE, MARSCHALL S. · 2008 to 2011
$44.6M
North Carolina Translational & Clinical Sciences Institute (NC TraCS)UL1TR001111 · NCATS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BUSE, JOHN BERNARD, CAREY, TIMOTHY S · 2013 to 2017
$43.9M
Yale University Clinical and Translational Science Award ProgramUL1TR000142 · NCATS · YALE UNIVERSITY · PI SHERWIN, ROBERT S · 2012 to 2015
$31.8M
UNC Clinical Translation Science Award-K12 Scholars Program (KL2)KL2RR025746 · NCRR · UNIV OF NORTH CAROLINA CHAPEL HILL · PI RUNGE, MARSCHALL S. · 2008 to 2011
$9.0M
North Carolina Translational & Clinical Sciences Institute (NC TraCS)KL2TR001109 · NCATS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BUSE, JOHN BERNARD, CAREY, TIMOTHY S · 2013 to 2017
$5.7M
Mentoring Junior Investigators: Comprehensive HIV PreventionK24HD069204 · NICHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI GOLIN, CAROL E · 2013 to 2017
$789k
An Adherence and Depression Intervention for Patients During Hepatitis C TherapyK23DK089004 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI EVON, DONNA MARIE · 2010 to 2013
$533k
NCATS NIH HHS KL2 TR001109NCATS NIH HHS UL1 TR000142NCATS NIH HHS UL1 TR001111NCRR NIH HHS KL2 RR025746NCRR NIH HHS UL1 RR025747NCRR NIH HHS UL1RR025747NIAID NIH HHS P30 AI050410NIAID NIH HHS P30-AI50410NICHD NIH HHS K24 HD069204NIDDK NIH HHS K23 DK089004NIDDK NIH HHS K23DK089004-02
6 · The paper itself

Abstract

goalsTo investigate the role of self-efficacy (SE) during hepatitis C virus (HCV) treatment.

backgroundAdherence to chronic HCV treatment is critical. SE is an important predictor of medication adherence in a number of chronic disease populations and medication regimens, but its role during HCV treatment remains unknown. STUDY: Data from the prospective Virahep-C study were analyzed to examine relationships between SE and patient-driven deviations (ie, missed doses measured using electronic pill caps, and nonpersistence) from adherence to HCV antiviral treatment. SE was measured using the 17-item HCV Treatment Self-Efficacy scale. This measure provides a global estimate of a patient's confidence to undergo and adhere to HCV treatment, and can estimate SE in 4 underlying domains: communication SE (ie, confidence to communicate with health care provider), physical coping SE (ie, confidence to cope with physical side effects), psychological coping SE (ie, confidence to cope with psychiatric side effects), and treatment adherence SE (ie, confidence to take all medications as prescribed and attend doctor visits). Generalized estimating equations and Cox proportional hazards models were used to assess associations between SE and missed doses and nonpersistence, respectively.

resultsSE was associated with being in a relationship, educated, privately insured, and less depressed. Higher communication SE at TW24 reduced the risk of missed doses between TW24 and TW48. Higher baseline treatment adherence SE reduced the likelihood of nonpersistence between baseline and TW24.

conclusionsSE's relationship to HCV treatment adherence has promising clinical and research implications.

Indexed as

Self EfficacyAntiviral AgentsCommunicationDepressionEducational StatusFemaleHepatitis C, ChronicHumansInsurance, HealthInterferonsInterpersonal RelationsMaleMedication AdherencePhysician-Patient RelationsPolyethylene GlycolsProportional Hazards ModelsAntiviral AgentsInterferonsPolyethylene GlycolsRibavirin

Identifiers

PMID24356458
PMCPMC4062612

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.