ArticleScientific reports2013
pH dependent transfer of nano-pores into membrane of cancer cells to induce apoptosis.
Article in Scientific reports, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 51 citations in OpenAlex.
- Engraftment of a surrogate antigen onto tumor cell surface via pHLIP peptide to universally target CAR-T cell therapy to solid tumors.Cancer letters · 2025Article
- Aiming the magic bullet: targeted delivery of imaging and therapeutic agents to solid tumors by pHLIP peptides.Frontiers in pharmacology · 2024Review
- Gramicidin A accumulates in mitochondria, reduces ATP levels, induces mitophagy, and inhibits cancer cell growth.Chemical science · 2022Article
- PD-1 blockage combined with vaccine therapy can facilitate immune infiltration in tumor microenvironment of Lynch syndrome colon cancer.Frontiers in genetics · 2022Article
- Review
- A Dual pH-Responsive DOX-Encapsulated Liposome Combined with Glucose Administration Enhanced Therapeutic Efficacy of Chemotherapy for Cancer.International journal of nanomedicine · 2021Article
- The impact of tumour pH on cancer progression: strategies for clinical intervention.Exploration of targeted anti-tumor therapy · 2020Review
- Cancer targeting peptides.Cellular and molecular life sciences : CMLS · 2019Review
- Decoration of Nanovesicles with pH (Low) Insertion Peptide (pHLIP) for Targeted Delivery.Nanoscale research letters · 2018Article
- Tumour acidosis: from the passenger to the driver's seat.Nature reviews. Cancer · 2017Review
- Synthesis and characterization of pHLIPBiochemistry and biophysics reports · 2017Article
- Rapid magnetic isolation of extracellular vesicles via lipid-based nanoprobes.Nature biomedical engineering · 2017Article
- Improving cancer therapies by targeting the physical and chemical hallmarks of the tumor microenvironment.Cancer letters · 2016Review
- Acidic pH-targeted chitosan capped mesoporous silica coated gold nanorods facilitate detection of pancreatic tumors via multispectral optoacoustic tomography.ACS biomaterials science & engineering · 2016Article
- Article
- The pH low insertion peptide pHLIP Variant 3 as a novel marker of acidic malignant lesions.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Advanced targeted nanomedicine.Journal of biotechnology · 2015Article
- Enhancement of radiation effect on cancer cells by gold-pHLIP.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Enhanced eryptosis following gramicidin exposure.Toxins · 2015Article
- Lipid headgroups modulate membrane insertion of pHLIP peptide.Biophysical journal · 2015Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Proper balance of ions in intracellular and extracellular space is the key for normal cell functioning. Changes in the conductance of membranes for ions will lead to cell death. One of the main differences between normal and cancerous cells is the low extracellular pHe and the reverse pH gradient: intracellular pHi is higher than extracellular pHe. We report here pH-selective transfer of nano-pores to cancer cells for the dis-regulation of balance of monovalent cations to induce cell death at mildly acidic pHe as it is in most solid tumors. Our approach is based on the pH-sensitive fusion of cellular membrane with the liposomes containing gramicidin A forming cation-conductive β-helix in the membrane. Fusion is promoted only at low extracellular pH by the pH (Low) Insertion Peptide (pHLIP®) attached to the liposomes. Gramicidin channels inserted into the cancer cells open flux of protons into the cytoplasm and disrupt balance of other monovalent cations, which induces cell apoptosis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.