Evidence map›Paper›PMID 24356070›Full record

ReviewNature reviews. Neuroscience2014

Branch management: mechanisms of axon branching in the developing vertebrate CNS.

Katherine Kalil, Erik W Dent

Abstract readReview
In one paragraph

Review in Nature reviews. Neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 160 papers.

0numbers the graph read from it
0cells of the map it votes in
160citing papers in PubMed
5.3field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

160 citing papers in PubMed, 299 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. A 16-amino acid peptide delays the progression of motor neuron degeneration and pathogenic symptoms in ALS models.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2026
    Article
  7. Article
  8. Article
  9. Article
  10. The actin assembly regulatorbioRxiv : the preprint server for biology · 2025
    Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Fidgetin binds spastin to attenuate the microtubule-severing activity.Biochimica et biophysica acta. Molecular cell research · 2025
    Article
  16. Article
  17. Review
  18. Oligodendrocytes: Myelination, Plasticity, and Axonal Support.Cold Spring Harbor perspectives in biology · 2024
    Review
  19. Article
  20. Article

100 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Katherine KalilDepartment of Neuroscience and Neuroscience Training Program, 1300 University Avenue, University of Wisconsin-Madison, Madison, Wisconsin 53706, USA.
Erik W DentDepartment of Neuroscience and Neuroscience Training Program, 1300 University Avenue, University of Wisconsin-Madison, Madison, Wisconsin 53706, USA.
University of Wisconsin–Madison · US

Funding

DEVELOPMENTAL STUDIES ON THE MOTOR SYSTEMR01NS014428 · NINDS · UNIVERSITY OF WISCONSIN-MADISON · PI KALIL, KATHERINE · 1985 to 2015
$3.6M
Role of F-BAR proteins in neuronal developmentR01NS080928 · NINDS · UNIVERSITY OF WISCONSIN-MADISON · PI DENT, ERIK W · 2013 to 2017
$1.6M
Cytoskeletal Dynamics in Neuronal DendritesR01NS064014 · NINDS · UNIVERSITY OF WISCONSIN-MADISON · PI DENT, ERIK W · 2009 to 2013
$1.6M
Developmental Studies on the Motor SystemR56NS014428 · NINDS · UNIVERSITY OF WISCONSIN-MADISON · PI KALIL, KATHERINE · 2010 to 2010
$361k
NINDS NIH HHS NS014428NINDS NIH HHS NS064014NINDS NIH HHS NS080928NINDS NIH HHS R01 NS014428NINDS NIH HHS R01 NS064014NINDS NIH HHS R01 NS080928NINDS NIH HHS R56 NS014428
6 · The paper itself

Abstract

The remarkable ability of a single axon to extend multiple branches and form terminal arbors enables vertebrate neurons to integrate information from divergent regions of the nervous system. Axons select appropriate pathways during development, but it is the branches that extend interstitially from the axon shaft and arborize at specific targets that are responsible for virtually all of the synaptic connectivity in the vertebrate CNS. How do axons form branches at specific target regions? Recent studies have identified molecular cues that activate intracellular signalling pathways in axons and mediate dynamic reorganization of the cytoskeleton to promote the formation of axon branches.

Indexed as

AnimalsAxonsBrainHumansNeurogenesisVertebrates

Identifiers

PMID24356070
PMCPMC4063290
OpenAlexW2025059340

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.