ArticleClinical nephrology2014
Relationship between heart rate variability and pulse wave velocity and their association with patient outcomes in chronic kidney disease.
Article in Clinical nephrology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- The Role of the Autonomic Nervous System in the Regulation of Aortic Stiffness.Hypertension (Dallas, Tex. : 1979) · 2016Trial
- The Usefulness of Falls Efficacy Scale-International in Predicting Falls in Chronic Kidney Disease Patients.Journal of clinical medicine · 2026Article
- Motor Coordination Disorders in Patients with Chronic Kidney Disease.Journal of clinical medicine · 2025Article
- Estimated Pulse Wave Velocity Is Associated With All-Cause Mortality and Cardiovascular Mortality Among Adults With Chronic Kidney Disease.Journal of clinical hypertension (Greenwich, Conn.) · 2025Article
- Pulse Wave Velocity: Methodology, Clinical Applications, and Interplay with Heart Rate Variability.Reviews in cardiovascular medicine · 2024Review
- Autonomic dysfunction is associated with the development of arterial stiffness: the Whitehall II cohort.GeroScience · 2023Article
- CENtral blood pressure Targeting: a pragmatic RAndomized triaL in advanced Chronic Kidney Disease (CENTRAL-CKD): A Clinical Research Protocol.Canadian journal of kidney health and disease · 2023Article
- Observational
- Association Between Arterial Stiffness and Measures of Autonomic Dysfunction in People With Chronic Kidney Disease.Canadian journal of kidney health and disease · 2023Article
- Aortic pulse wave velocity, central pulse pressure, augmentation index and chronic kidney disease progression in individuals with type 2 diabetes: a 3- year prospective study.BMC nephrology · 2020Article
- Response by Holwerda et al to Letter Regarding Article "Elevated Muscle Sympathetic Nerve Activity Contributes to Central Artery Stiffness in Young and Middle-Age/Older Adults".Hypertension (Dallas, Tex. : 1979) · 2019Article
- Sudden Cardiac Death in Dialysis: Arrhythmic Mechanisms and the Value of Non-invasive Electrophysiology.Frontiers in physiology · 2019Review
- Chronic Kidney Disease and Pulse Wave Velocity: A Narrative Review.International journal of hypertension · 2019Review
- Association of Pulse Wave Velocity With Chronic Kidney Disease Progression and Mortality: Findings From the CRIC Study (Chronic Renal Insufficiency Cohort).Hypertension (Dallas, Tex. : 1979) · 2018Article
- Heart Rate Variability and Its Relation to Chronic Kidney Disease: Results From the PREVEND Study.Psychosomatic medicine · 2018Article
- Rationale and study design of the prospective, longitudinal, observational cohort study "rISk strAtification in end-stage renal disease" (ISAR) study.BMC nephrology · 2016Observational
- The type of the functional cardiovascular response to upright posture is associated with arterial stiffness: a cross-sectional study in 470 volunteers.BMC cardiovascular disorders · 2016Article
- Reduced Baroreflex Sensitivity, Decreased Heart Rate Variability with Increased Arterial Stiffness in Predialysis.Indian journal of nephrologyArticle
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Authors and funding
11 authors.
Funding
Abstract
backgroundArterial stiffness and low heart rate variability (HRV) have each been associated with increased cardiovascular risk in a variety of patient populations. We explored the relationship between HRV and pulse wave velocity (PWV measure of arterial stiffness) in patients with chronic kidney disease (CKD prior to ESRD) along with examining their association with the outcomes of cardiovascular disease (CVD), death, and progression to end stage renal disease (ESRD).
methodsThe RRI-CKD Study is a 4-center prospective cohort study of CKD stages 3 - 5 (n = 834). A subset underwent both HRV testing by 24-hour Holter and carotid-femoral PWV (n = 240). Multiple linear regression was used to assess predictors of PWV and Cox regression to investigate the association of HRV and PWV with time to first CVD event or death and ESRD.
resultsAlthough several HRV measures were inversely correlated with PWV, this association was attenuated after adjustment for age and/or diabetes and no longer significant after adjustment for C-reactive protein. Low HRV and high PWV were individually associated with increased risk of the composite endpoint of CVD/death in multivariable analysis. The risk of the composite of CVD/death was highest for patients with both low HRV and high PWV.
conclusionAge, diabetes, and inflammation together explained the inverse association between HRV and PWV. Inflammation may play a role in the pathogenesis of both low HRV and high PWV. The combination of low HRV and high PWV showed the strongest association with a composite CVD outcome. Mechanisms underlying abnormalities in PWV and HRV, and the role of these measures as intermediate outcomes in future trials in CKD patients, merit further study.
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