ReviewFrontiers in neuroendocrinology2014
Disruption of fetal hormonal programming (prenatal stress) implicates shared risk for sex differences in depression and cardiovascular disease.
Review in Frontiers in neuroendocrinology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
43 citing papers in PubMed, 77 citations in OpenAlex.
- Respiratory-gated auricular vagal afferent nerve stimulation (RAVANS) modulates brain response to stress in major depression.Journal of psychiatric research · 2021Trial
- Socioeconomic disadvantage, gestational immune activity, and neurodevelopment in early childhood.Proceedings of the National Academy of Sciences of the United States of America · 2017Trial
- Maternal Stress During Pregnancy Induces Higher Anxiety-Like Behavior in Male Mice Offspring Under Acute Stress by Upregulating CRF/CRFR1 and Driving Time-Specific Activation of the MHb-IPN Circuit.Neuroscience bulletin · 2026Article
- Prenatal experience of greater neighborhood disadvantage is associated with altered fetal volumetric brain growth in utero.Cerebral cortex (New York, N.Y. : 1991) · 2026Article
- Maternal immune activation by toll-like receptor 7 agonist during mid-gestation increases susceptibility to blood-brain barrier leakage after puberty.Brain behavior and immunity integrative · 2024Article
- Maternal immune activation with toll-like receptor 7 agonist during mid-gestation alters juvenile and adult developmental milestones and behavior.Journal of neuroendocrinology · 2024Article
- Maternal Prenatal Depressive Symptoms and Fetal Growth During the Critical Rapid Growth Stage.JAMA network open · 2023Article
- Evaluating different models of maternal stress on stress-responsive systems in prepubertal mice.Frontiers in neuroscience · 2023Article
- Estrogen normalizes maternal HFD-induced vascular dysfunction in offspring by regulating ATR.Hypertension research : official journal of the Japanese Society of Hypertension · 2022Article
- Research Centers Collaborative Network Workshop on Sex and Gender Differences in Aging.Innovation in aging · 2022Article
- Maternal Immune activity during pregnancy and socioeconomic disparities in children's self-regulation.Brain, behavior, and immunity · 2020Article
- Roles for androgens in mediating the sex differences of neuroendocrine and behavioral stress responses.Biology of sex differences · 2020Review
- Impact of sex and depressed mood on the central regulation of cardiac autonomic function.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2020Article
- Sex-dependent associations between maternal prenatal cortisol and child callous-unemotional traits: Findings from the Wirral Child Health and Development Study.Psychoneuroendocrinology · 2019Article
- Correlates of low-adherence to oral hypoglycemic medications among Hispanic/Latinos of Mexican heritage with Type 2 Diabetes in the United States.Diabetes research and clinical practice · 2019Article
- Prenatal Stress, Mood, and Gray Matter Volume in Young Adulthood.Cerebral cortex (New York, N.Y. : 1991) · 2019Article
- Developmental origins of depression-related white matter properties: Findings from a prenatal birth cohort.Human brain mapping · 2019Article
- Sex differences in the hypothalamic-pituitary-adrenal axis' response to stress: an important role for gonadal hormones.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2019Review
- Sex differences in major depression and comorbidity of cardiometabolic disorders: impact of prenatal stress and immune exposures.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2019Review
- Effects of Estrogen in Gender-dependent Fetal Programming of Adult Cardiovascular Dysfunction.Current vascular pharmacology · 2019Review
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 1 country.
Funding
Abstract
Comorbidity of major depressive disorder (MDD) and cardiovascular disease (CVD) represents the fourth leading cause of morbidity and mortality worldwide, and women have a two times greater risk than men. Thus understanding the pathophysiology has widespread implications for attenuation and prevention of disease burden. We suggest that sex-dependent MDD-CVD comorbidity may result from alterations in fetal programming consequent to the prenatal maternal environments that produce excess glucocorticoids, which then drive sex-dependent developmental alterations of the fetal hypothalamic-pituitary-adrenal (HPA) axis circuitry impacting mood, stress regulation, autonomic nervous system (ANS), and the vasculature in adulthood. Evidence is consistent with the hypothesis that disruptions of pathways associated with gamma aminobutyric acid (GABA) in neuronal and vascular development and growth factors have critical roles in key developmental periods and adult responses to injury in heart and brain. Understanding the potential fetal origins of these sex differences will contribute to development of novel sex-dependent therapeutics.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.