ArticleAmerican journal of epidemiology2014
Invited commentary: is it time to retire the "pack-years" variable? Maybe not!
Article in American journal of epidemiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Functional Connectivity Disruptions in Grey Matter Volume-Altered Brain Regions Among Male Smokers: A Neuroimaging Study.Addiction biology · 2025Pooled it
- Overweight duration in older adults and cancer risk: a study of cohorts in Europe and the United States.European journal of epidemiology · 2016Pooled it
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- Surgical consensus for screening, diagnosis, staging, multimodal management and surveillance of early-stage resectable non-small cell lung cancer (NSCLC) in Malaysia.Translational lung cancer research · 2025Review
- Prevalence and Incidence of Metabolic Syndrome and Its Components Among Waterpipe Users.International journal of public health · 2024Article
- Prolonged smoldering Douglas fir smoke inhalation augments respiratory resistances, stiffens the aorta, and curbs ejection fraction in hypercholesterolemic mice.The Science of the total environment · 2023Article
- Association between cannabis use and blood pressure levels according to comorbidities and socioeconomic status.Scientific reports · 2023Article
- Increased spontaneous activity of the superior frontal gyrus with reduced functional connectivity to visual attention areas and cerebellum in male smokers.Frontiers in human neuroscience · 2023Article
- Association of Pack-Years of Cigarette Smoking With Survival and Tumor Progression Among Patients Treated With Chemoradiation for Head and Neck Cancer.JAMA network open · 2022Article
- Single-cell analysis of somatic mutations in human bronchial epithelial cells in relation to aging and smoking.Nature genetics · 2022Article
- Lifetime heavy drinking years predict alcohol use disorder severity over and above current alcohol use.The American journal of drug and alcohol abuse · 2021Article
- Article
- Intimate partner violence and lower relationship quality are associated with faster biological aging.Psychology and aging · 2020Article
- Association of Neighborhood Disadvantage in Childhood With DNA Methylation in Young Adulthood.JAMA network open · 2020Observational
- Smoking, air pollution, and lung cancer risk in the Nurses' Health Study cohort: time-dependent confounding and effect modification.Critical reviews in toxicology · 2020Review
- Modeling the Complex Exposure History of Smoking in Predicting Bladder Cancer: A Pooled Analysis of 15 Case-Control Studies.Epidemiology (Cambridge, Mass.) · 2019Article
- Risk of lung cancer in relation to various metrics of smoking history: a case-control study in Montreal.BMC cancer · 2018Article
- Dose-dependent effect of smoking on risk of coronary heart disease, heart failure and stroke in individuals with type 1 diabetes.Diabetologia · 2018Article
- Sweet flowers are slow, and weeds make haste: leveraging methodology from research on tobacco, alcohol, and opioid analgesics to make rapid and policy-relevant advances in cannabis science.International review of psychiatry (Abingdon, England) · 2018Review
- Synergistic and Non-synergistic Associations for Cigarette Smoking and Non-tobacco Risk Factors for Cardiovascular Disease Incidence in the Atherosclerosis Risk In Communities (ARIC) Study.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2017Article
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Abstract
Cumulative exposure--the product of intensity and duration for a constant exposure rate or its integral over time if variable--has been widely used in epidemiologic analyses of extended exposures, for example, the "pack-years" variable for tobacco smoking. Although the effects of intensity and duration are known to differ for exposures like smoking and ionizing radiation and simple cumulative exposure does not explicitly allow for modification by other time-related variables, such as age at exposure or time since exposure, the cumulative exposure variable has the merit of simplicity and has been shown to be one of the best predictors for many exposure-response relationships. This commentary discusses recent refinements of the pack-years variable, as discussed in this issue of the Journal by Vlaanderen et al. (Am J Epidemiol. 2014;179(3):290-298), in the broader context of general exposure-time-response relationships.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.