ArticleLipids in health and disease2013
Association study of angiotensin converting enzyme gene polymorphism with elderly diabetic hypertension and lipids levels.
Article in Lipids in health and disease, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 23 citations in OpenAlex.
- Article
- Article
- Association of ACE2 polymorphisms with susceptibility to essential hypertension and dyslipidemia in Xinjiang, China.Lipids in health and disease · 2018Article
- Daily sodium intake influences the relationship between angiotensin-converting enzyme gene insertion/deletion polymorphism and hypertension in older adults.Journal of clinical hypertension (Greenwich, Conn.) · 2018Article
- Central and peripheral pathogenetic forms of type 2 diabetes: a proof-of-concept study.Endocrine connections · 2016Article
- Association of the ACE rs4646994 and rs4341 polymorphisms with the progression of carotid atherosclerosis in slovenian patients with type 2 diabetes mellitus.Balkan journal of medical genetics : BJMG · 2015Article
- Identifying Common Genetic Risk Factors of Diabetic Neuropathies.Frontiers in endocrinology · 2015Review
- Article
- The relationship between ACE/AGT gene polymorphisms and the risk of diabetic retinopathy in Chinese patients with type 2 diabetes.Journal of the renin-angiotensin-aldosterone system : JRAASArticle
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
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Abstract
objectiveTo investigate the relationship between angiotensin converting enzyme (ACE) gene insertion/deletion (I/D) polymorphism and diabetic essential hypertension in elderly population.
methodsPolymerase chain reaction (PCR) technique was used in 260 elderly normal control patients, 205 elderly hypertensive patients and 138 elderly diabetic hypertensive patients to detect the I/D polymorphism in ACE gene.
resultsDD genotype frequency (0.352) and D allele frequency (0.543) in elderly hypertensive patients were higher than those in the normal control patients. DD genotype (0.421) and D allele frequency (0.579) in elderly diabetic hypertensive patients were significantly higher than those in the control patients (0.133 and 0.250). The differences of DD genotype and D allele frequency between the elderly hypertensive patients and the elderly diabetic hypertensive patients were not significant (P > 0.05).
conclusionACE gene deletion is a risk factor for hypertension but is not a risk factor for diabetes in elderly population.
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