Evidence map›Paper›PMID 24354724›Full record

ArticleActa paediatrica (Oslo, Norway : 1992)2014

Cerebral maturation on amplitude-integrated electroencephalography and perinatal exposures in preterm infants.

Lauren C Reynolds, Roberta G Pineda, Amit Mathur, Claudine Vavasseur, Divyen K Shah, Steve Liao, Terrie Inder

Abstract read
In one paragraph

Article in Acta paediatrica (Oslo, Norway : 1992), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. aEEG in the first 3 days after extremely preterm delivery relates to neurodevelopmental outcomes.Journal of perinatology : official journal of the California Perinatal Association · 2024
    Article
  2. Article
  3. Article
  4. Review
  5. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Lauren C ReynoldsDepartment of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA.
Roberta G Pineda
Amit Mathur
Claudine Vavasseur
Divyen K Shah
Steve Liao
Terrie Inder

Funding

Washington University Institute of Clinical and Translational SciencesUL1TR000448 · NCATS · WASHINGTON UNIVERSITY · PI EVANOFF, BRADLEY A · 2012 to 2016
$41.4M
Washington University Institute of Clinical and Translational SciencesKL2TR000450 · NCATS · WASHINGTON UNIVERSITY · PI EVANOFF, BRADLEY A · 2012 to 2016
$8.8M
Washington University Intellectual and Developmental Disabilities Research CenterP30HD062171 · NICHD · WASHINGTON UNIVERSITY · PI CONSTANTINO, JOHN N. · 2010 to 2014
$4.3M
UNDERSTANDING NEUROBEHAVIORAL DEFICITS IN PRETERM INFANTS THROUGH IMAGINGR01HD057098 · NICHD · WASHINGTON UNIVERSITY · PI INDER, TERRIE E, NEIL, JEFFREY J. · 2008 to 2012
$2.9M
NCATS NIH HHS KL2 TR000450NCATS NIH HHS UL1 TR000448NICHD NIH HHS P30 HD062171NICHD NIH HHS R01 HD057098NICHD NIH HHS R0I HD057098
6 · The paper itself

Abstract

aimTo determine the associations between perinatal exposures, cerebral maturation on amplitude-integrated encephalography (aEEG) and outcome.

methodsDuring this prospective cohort study, 136 infants ≤30 weeks estimated gestational age received 4 h of aEEG at four time points (between the first 2 weeks of life and term-equivalent age) during hospitalisation. Perinatal factors were documented. Associations between perinatal exposures and Burdjalov-scores were investigated. Neurodevelopmental outcome was assessed at the age of two.

resultsImmature cyclicity on the initial aEEG recording was associated with higher CRIB score (p = 0.01), vaginal delivery (p = 0.02), male gender (p < 0.01) and death (p = 0.01). Perinatal factors associated with lower Burdjalov-scores included cerebral injury (p < 0.01), sepsis (p < 0.01), lower caffeine dose (p = 0.006), prolonged mechanical ventilation (p = 0.002) and death (p < 0.01). Burdjalov-scores at 30 (β = 2.62, p < 0.01) and 34 weeks postmenstrual age (β = 2.89, p = 0.05) predicted motor scores.

conclusionaEEG measures of cyclicity and Burdjalov-scores in the first 6 weeks of life, with an emphasis on 30 and 34 weeks postmenstrual age, demonstrated associations with perinatal factors known to predict adverse neurodevelopmental outcome.

Indexed as

Birth InjuriesBrain InjuriesCerebrumElectroencephalographyFemaleHumansInfant, PrematureMaleProspective StudiesAmplitude-integrated electroencephalographyCerebral maturationNeonatal intensive carePerinatal exposurePreterm infant

Identifiers

PMID24354724
PMCPMC3945948

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.