ArticleJournal of clinical periodontology2014
Number of teeth, C-reactive protein, fibrinogen and cardiovascular mortality: a 15-year follow-up study in a Finnish cohort.
Article in Journal of clinical periodontology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 3 syntheses or guidelines pooled it, 50 citations in OpenAlex.
- Association between Dental and Cardiovascular Diseases: A Systematic Review.Reviews in cardiovascular medicine · 2023Pooled it
- Lower Number of Teeth Is Related to Higher Risks for ACVD and Death-Systematic Review and Meta-Analyses of Survival Data.Frontiers in cardiovascular medicine · 2021Pooled it
- Pooled it
- C-Reactive Protein in Saliva as a Non-Invasive Marker of Metabolic Syndrome: A Systematic Review and Meta-Analysis.Life (Basel, Switzerland) · 2026Review
- Strong Heart, Strong Smile: Tooth Loss and Incidence of CVD in American Indian Populations.Community dentistry and oral epidemiology · 2026Article
- Impact of posterior occlusal contact loss on cardiovascular disease using a Japanese claims database.Scientific reports · 2025Article
- Edentulism or Poor Oral Hygiene: Which Is the Stronger Predictor for All-Cause Mortality?Journal of clinical medicine · 2025Article
- Association of oral health with all-cause and cause-specific mortality in older Chinese adults: A 14-year follow-up of the Guangzhou Biobank Cohort study.Journal of global health · 2024Article
- Oral health as a modifiable risk factor for cardiovascular diseases.Trends in cardiovascular medicine · 2024Review
- Updates on the Role of Periodontitis-Related Epigenetics, Inflammation, Oral Microbiome, and Treatment in Cardiovascular Risk.Journal of inflammation research · 2024Review
- Number of Teeth According to Hand Strength in Adults: A Cross-Sectional Study of 11,499 South Korean Adults.Medicina (Kaunas, Lithuania) · 2023Article
- Oral hygiene, mouthwash usage and cardiovascular mortality during 18.8 years of follow-up.British dental journal · 2023Article
- Frailty mediated the association between tooth loss and mortality in the oldest old individuals: a cohort study.Frontiers in public health · 2023Article
- Article
- History of Periodontitis Diagnosis and Edentulism as Predictors of Cardiovascular Disease, Stroke, and Mortality in Postmenopausal Women.Journal of the American Heart Association · 2017Article
- The relationship between the number of natural teeth and airflow obstruction: a cross-sectional study using data from the Korean National Health and Nutrition Examination Survey.International journal of chronic obstructive pulmonary disease · 2016Article
- Dental infections may have detrimental consequences.Journal of the Royal Society of Medicine · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 5 institutions in 3 countries.
Funding
Abstract
aimTo test whether the number of teeth, an inverse proxy for composite oral infection scores is associated with better survival. MATERIALS AND
methodsThe Kuopio Oral Health and Heart study initiated a case-control study in 1995-1996 consisting of 256 consecutive coronary artery disease patients and 250 age and gender-matched controls. We appended the mortality data and formulated a longitudinal study. By May 31st, 2011, 124 mortalities had occurred and 80 of which were of cardiovascular origin. Using Cox proportional hazards models, we assessed the association of the teeth group (Teethgrp) - consisting of 10 teeth - with cardiovascular and all-cause mortality after 15.8 years of median follow-up.
resultsIn multivariate models, with the edentulous state as reference, one level increase in Teethgrp was associated with significantly increased survival from cardiovascular disease (CVD) mortality with a Hazard Ratio (HR) 0.73, p-value = 0.02 but not with all-cause mortality (HR = 0.87, p = 0.13). The findings were not mediated by C-reactive protein (CRP) levels ≥3 mg/L or by median fibrinogen levels, but were mediated by CRP levels >5 mg/L.
conclusionEach increment of 10 teeth from the edentulous state was associated with a 27% improved CVD survival, independent of low-grade systemic inflammation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.