Trial reportCommunity dentistry and oral epidemiology2014
High-fluoride toothpaste: a multicenter randomized controlled trial in adults.
Trial report in Community dentistry and oral epidemiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- How to Intervene in the Root Caries Process? Systematic Review and Meta-Analyses.Caries research · 2019Pooled it
- Systematic review on noninvasive treatment of root caries lesions.Journal of dental research · 2015Pooled it
- Efficacy of regular professional brushing by a dental nurse for 3 months in nursing home residents-A randomized, controlled clinical trial.International journal of dental hygiene · 2019Trial
- Intraoral fluoride levels after use of conventional and high-fluoride dentifrices.Clinical oral investigations · 2015Trial
- Dental Caries in Older Adults: A Narrative Review for Non-Dental Providers.International journal of environmental research and public health · 2026Review
- The Cariostatic Mechanisms of Fluoride-An Updated Review.Dentistry journal · 2026Review
- Preventive measures and perceived challenges in delivering oral health care for elderly patients: a survey of dental hygienists in Norway.Acta odontologica Scandinavica · 2025Article
- The influence of various sample storage conditions and sample bacterial contamination on concentrations of routine biochemical parameters.Journal of medical biochemistry · 2024Article
- Role of Fluoride in Dentistry: A Narrative Review.Cureus · 2023Review
- Impact of an Oral Hygiene Intervention in People with and without Dementia on Oral Health Parameters-Results from the Oral Health, Bite Force, and Dementia (OrBiD) Pilot Study.Journal of clinical medicine · 2022Article
- Article
- The Potential of Hydroxyapatite Toothpaste to Prevent Root Caries: A pH-Cycling Study.Clinical, cosmetic and investigational dentistry · 2021Article
- Validation of a Cariogenic Biofilm Model to Evaluate the Effect of Fluoride on Enamel and Root Dentine Demineralization.PloS one · 2016Article
- Relationship Between Receipt of 5,000 Ppm Sodium Fluoride Dentifrice Prescription and Time to First Dental Restoration among Older Adults: A Retrospective Cohort Study.Special care in dentistry : official publication of the American Association of Hospital Dentists, the Academy of Dentistry for the Handicapped, and the American Society for Geriatric DentistryArticle
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe aim of this single - blind, multicenter, parallel, randomized controlled trial was to evaluate the effectiveness of the application of a high-fluoride toothpaste on root caries in adults.
methodsAdult patients (n = 130, ♂ = 74, ♀ = 56; mean age ± SD: 56.9 ± 12.9) from three participating centers, diagnosed with root caries, were randomly allocated into two groups: Test (n = 64, ♂ = 37, ♀ = 27; lesions = 144; mean age: 59.0 ± 12.1; intervention: high-fluoride toothpaste with 5000 ppm F), and Control (n = 66, ♂ = 37, ♀ = 29; lesions = 160; mean age: 54.8 ± 13.5; intervention: regular-fluoride toothpaste with 1350 ppm F) groups. Clinical examinations and surface hardness scoring of the carious lesions were performed for each subject at specified time intervals (T0 - at baseline before intervention, T1 - at 3 months and T2 - at 6 months after intervention). Mean surface hardness scores (HS) were calculated for each patient. Statistical analyses comprised of two-way analysis of variance and post hoc comparisons using the Bonferroni-Dunn correction.
resultsAt T0 , there was no statistical difference between the two groups with regard to gender (P = 0.0682, unpaired t-test), or age (P = 0.9786, chi-squared test), and for the overall HS (Test group: HS = 3.4 ± 0.61; CONTROL GROUP: HS = 3.4 ± 0.66; P = 0.8757, unpaired t-test). The anova revealed significantly better HS for the test group than for the control groups (T1 : Test group: HS = 2.9 ± 0.67; CONTROL GROUP: HS = 3.1 ± 0.75; T2 : Test group: HS = 2.4 ± 0.81; CONTROL GROUP: HS = 2.8 ± 0.79; P < 0.0001). However, the interaction term time-point*group was not significant.
conclusionsThe application of a high-fluoride containing dentifrice (5000 ppm F) in adults, twice daily, significantly improves the surface hardness of otherwise untreated root caries lesions when compared with the use of regular fluoride containing (1350 ppm F) toothpastes.
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