ArticleAntioxidants & redox signaling2014
Mechanotransduction: forces, sensors, and redox signaling.
Article in Antioxidants & redox signaling, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 52 citations in OpenAlex.
- Use of Botulinum Toxin for Androgenic Alopecia: A Systematic Review.Skin appendage disorders · 2022Pooled it
- Efficacy of type A botulinum toxin treatment for androgenetic alopecia using ultrasound combined with trichoscopy.Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) · 2024Trial
- A comparison of normobaric and hypobaric hypoxia effects on cerebrovascular response pre and post maximal exercise.Experimental physiology · 2026Article
- Effects of Stress on Biological Characteristics and Metabolism of Periodontal Ligament Stem Cells of Deciduous Teeth.International dental journal · 2025Article
- Real-time monitoring of intracellular biochemical response in locally stretched single cell by a nanosensor.Analytical and bioanalytical chemistry · 2024Article
- The relationship of redox signaling with the risk for atherosclerosis.Frontiers in pharmacology · 2024Review
- Reactive oxygen species in endothelial signaling in COVID-19: Protective role of the novel peptide PIP-2.PloS one · 2024Article
- Harmonizing Magnetic Mitohormetic Regenerative Strategies: Developmental Implications of a Calcium-Mitochondrial Axis Invoked by Magnetic Field Exposure.Bioengineering (Basel, Switzerland) · 2023Review
- Bioinspired therapeutic platform based on extracellular vesicles for prevention of arterial wall remodeling in hypertension.Bioactive materials · 2022Article
- A novel experimental porcine model to assess the impact of differential pulmonary blood flow on ischemia-reperfusion injury after unilateral lung transplantation.Intensive care medicine experimental · 2021Article
- In Sickness and in Health: The Oxygen Reactive Species and the Bone.Frontiers in bioengineering and biotechnology · 2021Review
- Redox basis of exercise physiology.Redox biology · 2020Review
- Pulsed electromagnetic fields potentiate the paracrine function of mesenchymal stem cells for cartilage regeneration.Stem cell research & therapy · 2020Article
- Neutrophil-to-Lymphocyte Ratio: A Biomarker to Monitor the Immune Status of Astronauts.Frontiers in immunology · 2020Article
- Peroxiredoxin6 in Endothelial Signaling.Antioxidants (Basel, Switzerland) · 2019Review
- LGM2605 Reduces Space Radiation-Induced NLRP3 Inflammasome Activation and Damage in In Vitro Lung Vascular Networks.International journal of molecular sciences · 2019Article
- NADPH Oxidase Isoforms Are Involved in Glucocorticoid-Induced Preosteoblast Apoptosis.Oxidative medicine and cellular longevity · 2019Article
- Chicoric acid prevents PDGF-BB-induced VSMC dedifferentiation, proliferation and migration by suppressing ROS/NFκB/mTOR/P70S6K signaling cascade.Redox biology · 2018Article
- Endothelial Mechanotransduction, Redox Signaling and the Regulation of Vascular Inflammatory Pathways.Frontiers in physiology · 2018Review
- Redox Signaling and Its Impact on Skeletal and Vascular Responses to Spaceflight.International journal of molecular sciences · 2017Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mechanotransduction describes the molecular mechanisms by which cells response to changes in their physical environment by translating mechanical stimuli into biochemical signals. It is now clear that reactive oxygen species (ROS) and redox signaling play a crucial role in mechanotransduction analogous to their role in chemotransduction. This Forum has particular emphasis on ROS generation with altered mechanical stress, the upstream signal transduction pathways that initiate ROS production, and the downstream effectors that lead to physiological responses. There is particular emphasis on the role of ion channels in the initial response and the role of NADPH oxidases as the major source of ROS. The latter enzyme serves as the fulcrum of the mechanotransduction cascade. Although it seems likely that all cells are mechanosensitive to some degree, we have highlighted the responses of unicellular organisms (bacteria), bone cells, and particularly cells of the vasculature (endothelial cells and vascular smooth muscle cells). These cell types have been useful for studying the responses to altered osmotic pressure, hemodynamic pressure, shear stress, and compressive forces while exploring the link between signal transduction and physiological/pathophysiological responses.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.