ReviewGlobal spine journal2012
Improving the clinical evidence of bone graft substitute technology in lumbar spine surgery.
Review in Global spine journal, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03407560 (Use of the Bone Substitute SintLife® in Vertebral Arthrodesis Procedures. A Pilot Study.), which is not on this map. Cited by 33 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Use of the Bone Substitute SintLife® in Vertebral Arthrodesis Procedures. A Pilot Study.
Who cites it
33 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- A systematic review and meta-analysis of fusion rate enhancements and bone graft options for spine surgery.Scientific reports · 2022Pooled it
- Fusion rate and influence of surgery-related factors in lumbar interbody arthrodesis for degenerative spine diseases: a meta-analysis and systematic review.Musculoskeletal surgery · 2020Pooled it
- Evaluation of an increased strut porosity silicate-substituted calcium phosphate, SiCaP EP, as a synthetic bone graft substitute in spinal fusion surgery: a prospective, open-label study.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2019Trial
- Analysis of the effect of modified bone grafting in lateral lumbar interbody fusion: A retrospective comparative cohort study.BMC musculoskeletal disorders · 2025Article
- Article
- Bone fusion materials: past, present, and future.Asian spine journal · 2025Article
- BIOABSORBABLE CAGES IN SPINAL FUSION IN AN ANIMAL MODEL: A SYSTEMATIC REVIEW AND META-ANALYSIS.Acta ortopedica brasileira · 2025Review
- Does Bone Morphogenetic Protein Use Reduce Pseudarthrosis Rates in Single-Level Transforaminal Lumbar Interbody Fusion Surgeries?International journal of spine surgery · 2024Article
- Cellular Bone Matrix in Spine Surgery - Are They Worth the Risk: A Systematic Review.Global spine journal · 2024Review
- Finite element biomechanical analysis of 3D printed intervertebral fusion cage in osteoporotic population.BMC musculoskeletal disorders · 2024Article
- The benefit of antibiotic-combined Mg-hydroxyapatite bone graft substitute over autologous bone for surgical site infection prevention in posterolateral spinal fusion: a retrospective cohort study.Annals of medicine and surgery (2012) · 2023Article
- Biomechanical evaluation of different sizes of 3D printed cage in lumbar interbody fusion-a finite element analysis.BMC musculoskeletal disorders · 2023Article
- Peptide Enhanced Bone Graft Substitute Presents Improved Short-Term Increase in Bone Volume and Construct Stiffness Compared to Iliac Crest Autologous Bone in an Ovine Lumbar Interbody Fusion Model.Global spine journal · 2022Article
- Fusion assessment in standalone lateral lumbar interbody fusion: 3D-printed titanium versus polyetheretherketone (PEEK) cages.Journal of spine surgery (Hong Kong) · 2022Article
- Bone Morphogenetic Protein in Anterior Lumbar Interbody Fusions: A Propensity-Matched Medicare Outcome Analysis.International journal of spine surgery · 2022Article
- Physico-Chemical Characteristics and Posterolateral Fusion Performance of Biphasic Calcium Phosphate with Submicron Needle-Shaped Surface Topography Combined with a Novel Polymer Binder.Materials (Basel, Switzerland) · 2022Article
- Ceramic bone graft substitute (Mg-HA) in spinal fusion: A prospective pilot study.Frontiers in bioengineering and biotechnology · 2022Article
- Article
- Understanding the Future Prospects of Synergizing Minimally Invasive Transforaminal Lumbar Interbody Fusion Surgery with Ceramics and Regenerative Cellular Therapies.International journal of molecular sciences · 2021Review
- Surgical outcomes of two kinds of demineralized bone matrix putties/local autograft composites in instrumented posterolateral lumbar fusion.BMC musculoskeletal disorders · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bone graft substitutes have been used routinely for spine fusion for decades, yet clinical evidence establishing comparative data remains sparse. With recent scrutiny paid to the outcomes, complications, and costs associated with osteobiologics, a need to improve available data guiding efficacious use exists. We review the currently available clinical literature, studying the outcomes of various biologics in posterolateral lumbar spine fusion, and establish the need for a multicenter, independent osteobiologics registry.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.