Evidence map›Paper›PMID 24353895›Full record

ArticleChemical science2012

Biological stimuli and biomolecules in the assembly and manipulation of nanoscale polymeric particles.

Lyndsay M Randolph, Miao-Ping Chien, Nathan C Gianneschi

Abstract read
In one paragraph

Article in Chemical science, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Article
  2. Stimuli-Responsive Drug Release from Smart Polymers.Journal of functional biomaterials · 2019
    Review
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Stimuli-responsive nanomaterials for biomedical applications.Journal of the American Chemical Society · 2015
    Article
  11. Article
  12. Article
  13. Article
  14. Temperature-activated nucleic acid nanostructures.Journal of the American Chemical Society · 2013
    Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Lyndsay M RandolphDepartment of Chemistry and Biochemistry, University of California, San Diego, 9500 Gilman Dr, La Jolla, CA, 92093, USA.
Miao-Ping ChienDepartment of Chemistry and Biochemistry, University of California, San Diego, 9500 Gilman Dr, La Jolla, CA, 92093, USA.
Nathan C GianneschiDepartment of Chemistry and Biochemistry, University of California, San Diego, 9500 Gilman Dr, La Jolla, CA, 92093, USA.

Funding

Programming Pharmacokinetics in Vivo via In Situ Switching of Nanoscale ParticleDP2OD008724 · OD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GIANNESCHI, NATHAN CLAUDE · 2011 to 2011
$2.3M
EDAPT: Enzyme-Directed Assembly of Particle TheranosticsR01EB011633 · NIBIB · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI HALL, DAVID J · 2011 to 2014
$1.3M
NIBIB NIH HHS R01 EB011633NIH HHS DP2 OD008724
6 · The paper itself

Abstract

Living systems are replete with complex, stimuli-responsive nanoscale materials and molecular self-assemblies. There is an ever increasing and intense interest within the chemical sciences to understand, mimic and interface with these biological systems utilizing synthetic and/or semi-synthetic tools. Our aim in this review is to give perspective on this emerging field of research by highlighting examples of polymeric nanoparticles and micelles that are prepared utilizing biopolymers together with synthetic polymers for the purpose of developing nanomaterials capable of interacting and responding to biologically relevant stimuli. It is expected that with the merging of evolved biological molecules with synthetic materials, will come the ability to prepare complex, functional devices. A variety of applications will become accessible including self-healing materials, self-replicating systems, biodiagnostic tools, drug targeting materials and autonomous, adaptive sensors. Most importantly, the success of this type of strategy will impact how biomolecules are stabilized and incorporated into synthetic devices and at the same time, will influence how synthetic materials are utilized within biomedical applications.

Identifiers

PMID24353895
PMCPMC3864871

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.