ArticleNeuropsychiatric disease and treatment2013
Salivary alpha-amylase and cortisol responsiveness following electrically stimulated physical stress in bipolar disorder patients.
Article in Neuropsychiatric disease and treatment, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 21 citations in OpenAlex.
- Advancing the allostatic load model in military training research: from theory to application.Frontiers in physiology · 2025Review
- T2DM patients with depression have higher levels of hyperglycemia and cognitive decline than T2DM patients.PloS one · 2022Article
- Impacts of Interaction of Mental Condition and Quality of Life between Donors and Recipients at Decision-Making of Preemptive and Post-Dialysis Living-Donor Kidney Transplantation.Journal of personalized medicine · 2021Article
- Functional TSPO polymorphism predicts variance in the diurnal cortisol rhythm in bipolar disorder.Psychoneuroendocrinology · 2018Article
- Heart rate variability in bipolar disorder and borderline personality disorder: a clinical review.Evidence-based mental health · 2018Review
- Sex determines cortisol and alpha-amylase responses to acute physical and psychosocial stress in patients with avoidant personality disorder.Brain and behavior · 2016Article
- Transdermal neuromodulation of noradrenergic activity suppresses psychophysiological and biochemical stress responses in humans.Scientific reports · 2015Article
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Authors and funding
13 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundBipolar disorder (BP) is often associated with a change in hypothalamus- pituitary-adrenal axis function change due to chronic stress. Salivary α-amylase (sAA) levels increase in response to psychosocial stress and thus function as a marker of sympathoadrenal medullary system activity. However, sAA has been studied less often than salivary cortisol in BP patients.
methodWe measured Profile of Mood States and State-Trait Anxiety Inventory scores, heart rate variability, and salivary cortisol levels during electrical stimulation stress in 25 BP patients and 22 healthy volunteers.
resultsTension-anxiety, depression-dejection, anger-hostility, fatigue, and confusion scores in BP patients significantly increased compared with those of the healthy controls. In contrast, the vigor scores of BP patients significantly decreased compared with those of the healthy controls. Significant difference in the sAA levels was observed between BP patients and healthy controls. sAA of female patients was significantly higher than that of female healthy controls, and sAA in male patients tended to be higher than that of male healthy controls. No difference in salivary cortisol was observed between BP patients and the healthy controls. Only three time points were measured before and after the electrical stimulation stress. Furthermore, sAA secretion by BP patients increased before and after electrical stimulation.
conclusionThese preliminary results suggest that sAA may be a useful biological marker for BP patients.
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