ArticleJournal of neurophysiology2014
Thalamic olfaction: characterizing odor processing in the mediodorsal thalamus of the rat.
Article in Journal of neurophysiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed.
- A corticothalamic circuit modulates pain sensitivity and mediates innate fear-induced analgesia in male mice.Nature communications · 2026Article
- Integrating olfactory assessments in consciousness disorders: methodologies and therapeutic potential.Frontiers in neurology · 2026Review
- Progressive Changes Between Thalamic Nuclei and Cortical Networks Across Stimulus-Response Learning.Human brain mapping · 2025Article
- The evolution of cavefish odor perception shifts fish response from avoidance to approach when exposed to alarm and death odors.bioRxiv : the preprint server for biology · 2025Article
- Article
- Neural Processing of Taste-Related Signals in the Mediodorsal Thalamus of Mice.bioRxiv : the preprint server for biology · 2025Article
- Neuropathological lesions in intravenous BCG-stimulated K18-hACE2 mice challenged with SARS-CoV-2.Veterinary research · 2024Article
- When the central integrator disintegrates: A review of the role of the thalamus in cognition and dementia.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Review
- Open-source versatile 3D-print animal conditioning platform design for in vivo preclinical brain imaging in awake mice and anesthetized mice and rats.Lab animal · 2024Article
- Functional connectivity patterns in parosmia.Behavioral and brain functions : BBF · 2023Article
- The Olfactory Bulb in Companion Animals-Anatomy, Physiology, and Clinical Importance.Brain sciences · 2023Review
- Retinorecipient areas in the common marmoset (Frontiers in neural circuits · 2023Review
- State-dependent olfactory processing in freely behaving mice.Cell reports · 2022Article
- Reciprocal relationships between sleep and smell.Frontiers in neural circuits · 2022Review
- Thalamic activations in rat brain by fMRI during tactile (forepaw, whisker) and non-tactile (visual, olfactory) sensory stimulations.PloS one · 2022Article
- Cortical Hub for Flavor Sensation in Rodents.Frontiers in systems neuroscience · 2021Review
- Roles of the medial prefrontal cortex, mediodorsal thalamus, and their combined circuit for performance of the odor span task in rats: analysis of memory capacity and foraging behavior.Learning & memory (Cold Spring Harbor, N.Y.) · 2020Article
- A specific olfactory cortico-thalamic pathway contributing to sampling performance during odor reversal learning.Brain structure & function · 2019Article
- Experience-Dependent c-Fos Expression in the Mediodorsal Thalamus Varies With Chemosensory Modality.Chemical senses · 2019Article
- Article
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2 authors.
Funding
Abstract
Thalamus is a key crossroad structure involved in various functions relative to visual, auditory, gustatory, and somatosensory senses. Because of the specific organization of the olfactory pathway (i.e., no direct thalamic relay between sensory neurons and primary cortex), relatively little attention has been directed toward the thalamus in olfaction. However, an olfactory thalamus exists: the mediodorsal nucleus of the thalamus (MDT) receives input from various olfactory structures including the piriform cortex. How the MDT contributes to olfactory perception remains unanswered. The present study is a first step to gain insight into the function of the MDT in olfactory processing. Spontaneous and odor-evoked activities were recorded in both the MDT (single unit and local field potential) and the piriform cortex (local field potential) of urethane-anesthetized rats. We demonstrate that: 1) odorant presentation induces a conjoint, coherent emergence of beta-frequency-band oscillations in both the MDT and the piriform cortex; 2) 51% of MDT single units were odor-responsive with narrow-tuning characteristics across an odorant set, which included biological, monomolecular, and mixture stimuli. In fact, a majority of MDT units responded to only one odor within the set; 3) the MDT and the piriform cortex showed tightly related activities with, for example, nearly 20% of MDT firing in phase with piriform cortical beta-frequency oscillations; and 4) MDT-piriform cortex coherence was state-dependent with enhanced coupling during slow-wave activity. These data are discussed in the context of the hypothesized role of MDT in olfactory perception and attention.
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