ArticleEuropean heart journal2014
Prognostic models for stable coronary artery disease based on electronic health record cohort of 102 023 patients.
Article in European heart journal, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers, 5 of them syntheses that pooled it.
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Who cites it
60 citing papers in PubMed, 5 syntheses or guidelines pooled it, 140 citations in OpenAlex.
- Characteristics of Cardiovascular Disease Prediction Models Considering Mental Disorders: A Systematic Review.Journal of the American Heart Association · 2026Pooled it
- β-blocker and clinical outcomes in patients after myocardial infarction: a systematic review and meta-analysis.European journal of clinical pharmacology · 2025Pooled it
- Individualized Prediction of Transition to Psychosis in 1,676 Individuals at Clinical High Risk: Development and Validation of a Multivariable Prediction Model Based on Individual Patient Data Meta-Analysis.Frontiers in psychiatry · 2019Pooled it
- Mortality and morbidity trends after the first year in survivors of acute myocardial infarction: a systematic review.BMC cardiovascular disorders · 2017Pooled it
- Opportunities and challenges in developing risk prediction models with electronic health records data: a systematic review.Journal of the American Medical Informatics Association : JAMIA · 2017Pooled it
- Plasma Protein Biomarkers and Long-Term Cardiovascular Mortality Risk in Patients With Chronic Coronary Heart Disease.Journal of the American Heart Association · 2024Trial
- Cost-effectiveness of ticagrelor in patients with type 2 diabetes and coronary artery disease: a European economic evaluation of the THEMIS trial.European heart journal. Cardiovascular pharmacotherapy · 2022Trial
- Inhalation of ultrafine carbon particles alters heart rate and heart rate variability in people with type 2 diabetes.Particle and fibre toxicology · 2014Trial
- Prognostic value of pretest probability of heart failure with preserved ejection fraction in patients with coronary artery disease: an insight from the CLIDAS-PCI database.Cardiovascular intervention and therapeutics · 2026Article
- Usefulness of the AHEAD score for prediction of all-cause death in patients with acute and chronic coronary syndromes.International journal of cardiology. Cardiovascular risk and prevention · 2025Article
- Clinical value of a comprehensive clinical- and echocardiography-based risk score on predicting cardiovascular outcomes in ischemic heart failure patients with reduced ejection fraction.Clinical research in cardiology : official journal of the German Cardiac Society · 2025Article
- Estimated impact of guidelines-based initiation of dual antihypertensive therapy on long-term cardiovascular outcomes in 1.1 million individuals.European heart journal. Cardiovascular pharmacotherapy · 2025Article
- Plasma Levels of Propionylcarnitine Improved Prediction of Heart Failure and All-Cause Mortality in Patients with Stable Coronary Artery Disease.Biomolecules · 2024Article
- Risk factors for mortality in post-myocardial infarction patients: insights from the improve SCA bridge study.The Egyptian heart journal : (EHJ) : official bulletin of the Egyptian Society of Cardiology · 2024Article
- Interaction of impaired myocardial flow reserve and extent of myocardial ischemia assessed usingJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2023Article
- Determining cardiovascular risk in patients with unattributed chest pain in UK primary care: an electronic health record study.European journal of preventive cardiology · 2023Article
- Transparent reporting of multivariable prediction models developed or validated using clustered data: TRIPOD-Cluster checklist.BMJ (Clinical research ed.) · 2023Article
- Age-Bilirubin-International Normalized Ratio (INR)-Creatinine (ABIC) Score, a Potential Prognostic Model for Long-Term Mortality of CAD Patients After PCI.Journal of inflammation research · 2023Article
- Long-Term Cardiovascular Risk and Management of Patients Recorded in Primary Care With Unattributed Chest Pain: An Electronic Health Record Study.Journal of the American Heart Association · 2022Article
- Development and Validation of a Prediction Rule for Major Adverse Cardiac and Cerebrovascular Events in High-Risk Myocardial Infarction Patients After Primary Percutaneous Coronary Intervention.Clinical interventions in aging · 2022Observational
Corrections and comments
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Authors and funding
12 authors at 3 institutions in 1 country.
Funding
Abstract
aimsThe population with stable coronary artery disease (SCAD) is growing but validated models to guide their clinical management are lacking. We developed and validated prognostic models for all-cause mortality and non-fatal myocardial infarction (MI) or coronary death in SCAD. METHODS AND
resultsModels were developed in a linked electronic health records cohort of 102 023 SCAD patients from the CALIBER programme, with mean follow-up of 4.4 (SD 2.8) years during which 20 817 deaths and 8856 coronary outcomes were observed. The Kaplan-Meier 5-year risk was 20.6% (95% CI, 20.3, 20.9) for mortality and 9.7% (95% CI, 9.4, 9.9) for non-fatal MI or coronary death. The predictors in the models were age, sex, CAD diagnosis, deprivation, smoking, hypertension, diabetes, lipids, heart failure, peripheral arterial disease, atrial fibrillation, stroke, chronic kidney disease, chronic pulmonary disease, liver disease, cancer, depression, anxiety, heart rate, creatinine, white cell count, and haemoglobin. The models had good calibration and discrimination in internal (external) validation with C-index 0.811 (0.735) for all-cause mortality and 0.778 (0.718) for non-fatal MI or coronary death. Using these models to identify patients at high risk (defined by guidelines as 3% annual mortality) and support a management decision associated with hazard ratio 0.8 could save an additional 13-16 life years or 15-18 coronary event-free years per 1000 patients screened, compared with models with just age, sex, and deprivation.
conclusionThese validated prognostic models could be used in clinical practice to support risk stratification as recommended in clinical guidelines.
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