ArticleCellular oncology (Dordrecht, Netherlands)2014
Genetic gains and losses in oral squamous cell carcinoma: impact on clinical management.
Article in Cellular oncology (Dordrecht, Netherlands), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 55 citations in OpenAlex.
- TUSC3, p53 and p21 genetic association with development of oral submucous fibrosis and oral squamous cell carcinoma among addictive tobacco chewers of Pakistan.BMC oral health · 2024Article
- Genomic alterations in the stepwise progression from normal mucosa to metastasizing oral squamous cell carcinoma.Frontiers in oncology · 2024Article
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- The role of macrophage scavenger receptor 1 (MSR1) in inflammatory disorders and cancer.Frontiers in immunology · 2022Review
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- Upper aerodigestive tract carcinoma: Development of a (epi)genomic predictive model for recurrence and metastasis.Oncology letters · 2020Article
- The oncogene BCL6 is up-regulated in glioblastoma in response to DNA damage, and drives survival after therapy.PloS one · 2020Article
- (Cyto)genomic and epigenetic characterization of BICR 10 cell line and three new established primary human head and neck squamous cell carcinoma cultures.Genes & genomics · 2019Article
- Cytogenetics and Cytogenomics Evaluation in Cancer.International journal of molecular sciences · 2019Review
- Integrative Copy Number Analysis of Uveal Melanoma Reveals Novel Candidate Genes Involved in Tumorigenesis Including a Tumor Suppressor Role forClinical cancer research : an official journal of the American Association for Cancer Research · 2019Article
- Head and neck cancer: searching for genomic and epigenetic biomarkers in body fluids - the state of art.Molecular cytogenetics · 2019Review
- A Novel RNF139 Mutation in Hemangioblastomas: Case Report.Frontiers in neurology · 2019Article
- Tumor suppressor candidate 3: A novel grading tool and predictor of clinical malignancy in human gliomas.Oncology letters · 2018Article
- TUSC3: functional duality of a cancer gene.Cellular and molecular life sciences : CMLS · 2018Review
- Genome-wide screening for genomic aberrations in Kazakh patients with esophageal squamous cell cancer by comparative genomic hybridization.International journal of clinical and experimental pathology · 2018Article
- Genomic and epigenetic signatures associated with survival rate in oral squamous cell carcinoma patients.Journal of Cancer · 2018Article
- MicroRNA-132 induces temozolomide resistance and promotes the formation of cancer stem cell phenotypes by targeting tumor suppressor candidate 3 in glioblastoma.International journal of molecular medicine · 2017Article
- Genomic profile of oral squamous cell carcinomas with an adjacent leukoplakia or with an erythroleukoplakia that evolved after the treatment of primary tumor: A report of two cases.Molecular medicine reports · 2017Article
- Genomic predictive model for recurrence and metastasis development in head and neck squamous cell carcinoma patients.Scientific reports · 2017Article
- TUSC3: a novel tumour suppressor gene and its functional implications.Journal of cellular and molecular medicine · 2017Review
Corrections and comments
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Authors and funding
12 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe identification of genetic markers associated with oral cancer is considered essential to improve the diagnosis, prognosis, early tumor and relapse detection and, ultimately, to delineate individualized therapeutic approaches. Here, we aimed at identifying such markers.
methodsMultiplex Ligation-dependent Probe Amplification (MLPA) analyses encompassing 133 cancer-related genes were performed on a panel of primary oral tumor samples and its corresponding resection margins (macroscopically tumor-free tissue) allowing, in both types of tissue, the detection of a wide arrange of copy number imbalances on various human chromosomes.
resultsWe found that in tumor tissue, from the 133 cancer-related genes included in this study, those that most frequently exhibited copy number gains were located on chromosomal arms 3q, 6p, 8q, 11q, 16p, 16q, 17p, 17q and 19q, whereas those most frequently exhibiting copy number losses were located on chromosomal arms 2q, 3p, 4q, 5q, 8p, 9p, 11q and 18q. Several imbalances were highlighted, i.e., losses of ERBB4, CTNNB1, NFKB1, IL2, IL12B, TUSC3, CDKN2A, CASP1, and gains of MME, BCL6, VEGF, PTK2, PTP4A3, RNF139, CCND1, FGF3, CTTN, MVP, CDH1, BRCA1, CDKN2D, BAX, as well as exon 4 of TP53. Comparisons between tumor and matched macroscopically tumor-free tissues allowed us to build a logistic regression model to predict the tissue type (benign versus malignant). In this model, the TUSC3 gene showed statistical significance, indicating that loss of this gene may serve as a good indicator of malignancy.
conclusionsOur results point towards relevance of the above mentioned cancer-related genes as putative genetic markers for oral cancer. For practical clinical purposes, these genetic markers should be validated in additional studies.
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