ArticleDepression and anxiety2014
The effect of gender, age, and symptom severity in late-life depression on the risk of all-cause mortality: the Bambuí Cohort Study of Aging.
Article in Depression and anxiety, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
37 citing papers in PubMed, 72 citations in OpenAlex.
- Association of Molecular Senescence Markers in Late-Life Depression With Clinical Characteristics and Treatment Outcome.JAMA network open · 2022Trial
- Association of depressive disorder with biochemical and anthropometric indices in adult men and women.Scientific reports · 2021Trial
- Late-life depression and risk of all-cause and cause-specific mortality in an Asian population: the Singapore Chinese Health Study.BMJ public health · 2026Article
- Perceived stress mediates the association between orbitofrontal cortex grey matter volume and depressive symptoms in older women.Scientific reports · 2025Article
- Study on depression-free life expectancy in the elderly population in China.BMC public health · 2025Article
- Systemic Inflammation at the Crossroad of Major Depressive Disorder and Comorbidities: A Narrative Review.International journal of molecular sciences · 2025Review
- Zinc deficiency as possible link between immunosenescence and age-related diseases.Immunity & ageing : I & A · 2025Review
- Causes of death in individuals with lifetime major depression: a comprehensive machine learning analysis from a community-based autopsy center.BMC psychiatry · 2024Article
- Association between depressive symptoms and all-cause mortality in Chilean adult population: prospective results from two national health surveys.Social psychiatry and psychiatric epidemiology · 2024Article
- Sex differences in plasma proteomic markers in late-life depression.Psychiatry research · 2024Article
- Behavioral Impairments and Increased Risk of Cortical Atrophy Risk Scores Among World Trade Center Responders.Journal of geriatric psychiatry and neurology · 2024Article
- Geroscience-Centric Perspective for Geriatric Psychiatry: Integrating Aging Biology With Geriatric Mental Health Research.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2024Review
- Resting-state functional connectivity of the cerebellum-cerebrum in older women with depressive symptoms.BMC psychiatry · 2023Article
- Major depression, physical health and molecular senescence markers abnormalities.Nature. Mental health · 2023Article
- Protein phosphatase 2A activators reverse age-related behavioral changes by targeting neural cell senescence.Aging cell · 2023Article
- Major depression and the biological hallmarks of aging.Ageing research reviews · 2023Review
- Associations between depressive symptoms and disease progression in older patients with chronic kidney disease: results of the EQUAL study.Clinical kidney journal · 2022Article
- [Depressive symptoms and mortality in older people in Latin America: systematic review and meta-analysisSíntomas de depresión y mortalidad en personas mayores en América Latina: revisión sistemática con metanálisis].Revista panamericana de salud publica = Pan American journal of public health · 2022Review
- Role of leukocytes, gender, and symptom domains in the influence of depression on hospitalization and mortality risk: Findings from the Moli-sani study.Frontiers in psychiatry · 2022Article
- Telomere shortening in late-life depression: A potential marker of depression severity.Brain and behavior · 2021Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundIncreased mortality risk and its moderators is an important, but still under recognized, negative outcome of late-life depression (LLD). Therefore, we aimed to evaluate whether LLD is a risk factor for all-cause mortality in a population-based study with over 10 years of follow-up, and addressed the moderating effect of gender and symptom severity on mortality risk.
methodsThis analysis used data from the Bambuí Cohort Study of Aging. The study population comprised 1.508 (86.5%) of all eligible 1.742 elderly residents. Depressive symptoms were annually evaluated by the GHQ-12, with scores of five or higher indicating clinically significant depression. From 1997 to 2007, 441 participants died during 10,648 person-years of follow-up. We estimated the hazard ratio for mortality risk by Cox regression analyses.
resultsDepressive symptoms were a risk factor for all-cause mortality after adjusting for confounding lifestyle and clinical factors (adjusted HR = 1.24 CI95% [1.00-1.55], P = .05). Mortality risk was significantly elevated in men (adjusted HR = 1.45 CI95% [1.01-2.07], P = 0.04), but not in women (adjusted HR = 1.13 CI95% [0.84-1.48], P = 0.15). We observed a significant interaction between gender and depressive symptoms on mortality risk ((HR = 1.72 CI95% [1.18-2.49], P = 0.004).
conclusionThe present study provides evidence that LLD is a risk factor for all-cause mortality in the elderly, especially in men. The prevention and adequate treatment of LLD may help to reduce premature disability and death among elders with depressive symptoms.
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