Evidence map›Paper›PMID 24352756›Full record

ArticleBone & joint research2013

Negative pressure wound therapy for managementof the surgical incision in orthopaedic surgery: A review of evidence and mechanisms for an emerging indication.

S Karlakki, M Brem, S Giannini, V Khanduja, J Stannard, R Martin

2 registry-linked trialsOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bone & joint research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 60 papers, 11 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
60citing papers in PubMed, 11 pooled it
11.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03061903 nacompletednot on this mapstarted 2018, after this paper: background citation

Closed Incision Negative Pressure Therapy vs. Standard of Care for Surgical Incision Management in High-Risk Patients Following Total Hip Arthroplasty: A Randomized Controlled Trial

TypeinterventionalSponsorColumbia UniversityRan2018 to 2022Enrolled122ConditionsWound ComplicationArmsPrevena, Aquacel
NCT04618406 nacompletednot on this mapstarted 2021, after this paper: background citation

The Effect of Negative Pressure Wound Therapy on Wound Healing in Major Amputations

TypeinterventionalSponsorUniversity of Southern DenmarkRan2021 to 2025Enrolled158ConditionsNegative-Pressure Wound Therapy, Amputation, Wound HealArmsPICO VAC, Standard care
3 · Its place in the literature

Who cites it

60 citing papers in PubMed, 11 syntheses or guidelines pooled it, 127 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 6 institutions in 4 countries.

S KarlakkiRobert Jones Agnes Hunt Orthopaedic Hospital, ArthroplastyDepartment, Oswestry SY10 7AG, UK.
M Brem
S Giannini
V Khanduja
J Stannard
R Martin
Addenbrooke's Hospital · GBAdvanced Micro Devices (United Kingdom) · GBFriedrich-Alexander-Universität Erlangen-Nürnberg · DEIstituto Ortopedico Rizzoli · ITRobert Jones and Agnes Hunt Orthopaedic Hospital · GBUniversity of Missouri Health System · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesThe period of post-operative treatment before surgical wounds are completely closed remains a key window, during which one can apply new technologies that can minimise complications. One such technology is the use of negative pressure wound therapy to manage and accelerate healing of the closed incisional wound (incisional NPWT).

methodsWe undertook a literature review of this emerging indication to identify evidence within orthopaedic surgery and other surgical disciplines. Literature that supports our current understanding of the mechanisms of action was also reviewed in detail.

resultsA total of 33 publications were identified, including nine clinical study reports from orthopaedic surgery; four from cardiothoracic surgery and 12 from studies in abdominal, plastic and vascular disciplines. Most papers (26 of 33) had been published within the past three years. Thus far two randomised controlled trials - one in orthopaedic and one in cardiothoracic surgery - show evidence of reduced incidence of wound healing complications after between three and five days of post-operative NPWT of two- and four-fold, respectively. Investigations show that reduction in haematoma and seroma, accelerated wound healing and increased clearance of oedema are significant mechanisms of action.

conclusionsThere is a rapidly emerging literature on the effect of NPWT on the closed incision. Initiated and confirmed first with a randomised controlled trial in orthopaedic trauma surgery, studies in abdominal, plastic and vascular surgery with high rates of complications have been reported recently. The evidence from single-use NPWT devices is accumulating. There are no large randomised studies yet in reconstructive joint replacement. Cite this article: Bone Joint Res 2013;2:276-84.

Indexed as

Incisional NPWTMechanism of actionNegative pressure wound therapyNPWTSingle-use NPWTSurgical site infection

Identifiers

PMID24352756
PMCPMC3884878
OpenAlexW2123367866

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.