ArticleJournal of the Royal Society, Interface2014
Modelling the mechanics of partially mineralized collagen fibrils, fibres and tissue.
Article in Journal of the Royal Society, Interface, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
51 citing papers in PubMed.
- A designable twist-densification route to bioactive collagen hydrogel yarns approaching tendon-like mechanics.Bioactive materials · 2027Article
- Article
- Understanding the effects of mineralization and structure on the mechanical properties of tendon-bone insertion using mesoscale computational modeling.Journal of the mechanical behavior of biomedical materials · 2024Article
- Achieving tendon enthesis regeneration across length scales.Current opinion in biomedical engineering · 2024Article
- Python tooth-inspired fixation device for enhanced rotator cuff repair.Science advances · 2024Article
- Effect of chitosan and CMCS on dentin after Er:YAG laser irradiation: shear bond strength and surface morphology analysis.BMC oral health · 2024Article
- Effect of polyhydroxy-terminated PAMAM dendrimer on dentin matrix metalloproteinases within the hybrid layers.BMC oral health · 2023Article
- Acoustic radiation force on a long cylinder, and potential sound transduction by tomato trichomes.Biophysical journal · 2022Article
- Toughening mechanisms for the attachment of architectured materials: The mechanics of the tendon enthesis.Science advances · 2021Article
- Stem cell therapies in tendon-bone healing.World journal of stem cells · 2021Review
- Joining soft tissues to bone: Insights from modeling and simulations.Bone reports · 2021Review
- Percolation networks inside 3D model of the mineralized collagen fibril.Scientific reports · 2021Article
- Nanofiber Scaffolds by Electrospinning for Rotator Cuff Tissue Engineering.Chonnam medical journal · 2021Review
- Designing a novel vacuum aspiration system to decellularize large-size enthesis with preservation of physicochemical and biological properties.Annals of translational medicine · 2020Article
- Spatiotemporally Controlled Photoresponsive Hydrogels: Design and Predictive Modeling from Processing through Application.Advanced functional materials · 2020Review
- Microstructure, mineral and mechanical properties of teleost intermuscular bones.Journal of biomechanics · 2019Article
- Understanding the Stiff-to-Compliant Transition of the Meniscal Attachments by Spatial Correlation of Composition, Structure, and Mechanics.ACS applied materials & interfaces · 2019Article
- Helical nanofiber yarn enabling highly stretchable engineered microtissue.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Remineralization of demineralized dentin using a dual analog system.Orthodontics & craniofacial research · 2019Article
- Adhesive-based tendon-to-bone repair: failure modelling and materials selection.Journal of the Royal Society, Interface · 2019Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Progressive stiffening of collagen tissue by bioapatite mineral is important physiologically, but the details of this stiffening are uncertain. Unresolved questions about the details of the accommodation of bioapatite within and upon collagen's hierarchical structure have posed a central hurdle, but recent microscopy data resolve several major questions. These data suggest how collagen accommodates bioapatite at the lowest relevant hierarchical level (collagen fibrils), and suggest several possibilities for the progressive accommodation of bioapatite at higher hierarchical length scales (fibres and tissue). We developed approximations for the stiffening of collagen across spatial hierarchies based upon these data, and connected models across hierarchies levels to estimate mineralization-dependent tissue-level mechanics. In the five possible sequences of mineralization studied, percolation of the bioapatite phase proved to be an important determinant of the degree of stiffening by bioapatite. The models were applied to study one important instance of partially mineralized tissue, which occurs at the attachment of tendon to bone. All sequences of mineralization considered reproduced experimental observations of a region of tissue between tendon and bone that is more compliant than either tendon or bone, but the size and nature of this region depended strongly upon the sequence of mineralization. These models and observations have implications for engineered tissue scaffolds at the attachment of tendon to bone, bone development and graded biomimetic attachment of dissimilar hierarchical materials in general.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.