Hydroxyethyl starch: putting patient safety first.

Julian Bion, Rinaldo Bellomo, John Myburgh, Anders Perner, Konrad Reinhart, Simon Finfer

Abstract read

In one paragraph

Article in Intensive care medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it

0cells of the map it votes in

8citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

Long-term outcomes in patients with severe sepsis randomised to resuscitation with hydroxyethyl starch 130/0.42 or Ringer's acetate.Intensive care medicine · 2014
Trial
Lactated Ringer's Solution Reduces Severity, Mortality, Systemic and Local Complications in Acute Pancreatitis: A Systematic Review and Meta-Analysis.Biomedicines · 2023
Review
Understanding the Harms of HES: A Review of the Evidence to Date.Turkish journal of anaesthesiology and reanimation · 2019
Review
Starch Wars-New Episodes of the Saga. Changes in Regulations on Hydroxyethyl Starch in the European Union.Frontiers in veterinary science · 2018
Review
Is the literature inconclusive about the harm of HES? We are not sure.Intensive care medicine · 2017
Article
The intensive care medicine research agenda on septic shock.Intensive care medicine · 2017
Review
Impact of perioperative administration of 6 % hydroxyethyl starch 130/0.4 on serum cystatin C-derived renal function after radical prostatectomy: a single-centre retrospective study.BMC anesthesiology · 2016
Article
Inflammatory Kidney and Liver Tissue Response to Different Hydroxyethylstarch (HES) Preparations in a Rat Model of Early Sepsis.PloS one · 2016
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Julian BionUniversity of Birmingham, Birmingham, UK. j.f.bion@bham.ac.uk.

Rinaldo BellomoUniversity of Melbourne, Melbourne, Australia.

John MyburghThe George Institute for Global Health and the University of New South Wales, Sydney, Australia.

Anders PernerRigshospitalet, University of Copenhagen, Copenhagen, Denmark.

Konrad ReinhartFriedrich Schiller University, Jena, Germany.

Simon FinferRoyal North Shore Hospital and The George Institute for Global Health, University of Sydney, Sydney, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Patient SafetyPharmacovigilanceEuropeHumansHydroxyethyl Starch DerivativesPlasma SubstitutesHydroxyethyl Starch DerivativesPlasma Substitutes

Identifiers

PMID24352482

DOI10.1007/s00134-013-3167-6

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.