Evidence map›Paper›PMID 24352077›Full record

ArticleThe Journal of investigative dermatology2014

A new light on an old disease: adhesion signaling in pemphigus vulgaris.

Arnaud Galichet, Luca Borradori, Eliane J Müller

Abstract readComment
PubMed Publisher
In one paragraph

Article in The Journal of investigative dermatology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Arnaud GalichetVetsuisse Faculty, Molecular Dermatology and Stem Cell Research, Institute of Animal Pathology, University Hospital of Bern, Bern, Switzerland; DermFocus University of Bern, University Hospital of Bern, Bern, Switzerland.
Luca BorradoriDermFocus University of Bern, University Hospital of Bern, Bern, Switzerland; Department of Dermatology, University Hospital of Bern, Bern, Switzerland.
Eliane J MüllerVetsuisse Faculty, Molecular Dermatology and Stem Cell Research, Institute of Animal Pathology, University Hospital of Bern, Bern, Switzerland; DermFocus University of Bern, University Hospital of Bern, Bern, Switzerland. Electronic address: eliane.mueller@vetsuisse.unibe.ch.
University of Bern · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Disruption of desmosomal cadherin adhesion leads to the activation of intracellular signaling pathways that are responsible for blister formation in pemphigus vulgaris (PV). Recent studies corroborate the implication of the p38 mitogen-activated protein kinase in PV blistering via its downstream effector mitogen-activated protein kinase activated protein kinase 2. These insights highlight the key role of cadherins in tissue homeostasis and are expected to change pemphigus management.

Indexed as

AnimalsBlisterHumansIntracellular Signaling Peptides and ProteinsKeratinocytesMAP-Kinase-Activated Kinase 2PemphigusProtein Serine-Threonine KinasesSignal TransductionIntracellular Signaling Peptides and ProteinsMAP-Kinase-Activated Kinase 2Protein Serine-Threonine Kinases

Identifiers

PMID24352077
OpenAlexW2038658651

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.