ArticleProceedings of the National Academy of Sciences of the United States of America2014
Drastic neofunctionalization associated with evolution of the timezyme AANAT 500 Mya.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 59 citations in OpenAlex.
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- Adaptive Evolution of the Greater Horseshoe BatAnimals : an open access journal from MDPI · 2024Article
- Melatonin: Facts, Extrapolations and Clinical Trials.Biomolecules · 2023Review
- Functional Characterization of SerotoninAntioxidants (Basel, Switzerland) · 2022Article
- Evolutionary Genomics Reveals Multiple Functions of ArylalkylamineFrontiers in genetics · 2022Review
- New Insights Into the Evolutionary History of Melatonin Receptors in Vertebrates, With Particular Focus on Teleosts.Frontiers in endocrinology · 2020Review
- Effects of Melatonin on Anterior Pituitary Plasticity: A Comparison Between Mammals and Teleosts.Frontiers in endocrinology · 2020Review
- A Comparative Genomics Study on the Molecular Evolution of Serotonin/Melatonin Biosynthesizing Enzymes in Vertebrates.Frontiers in molecular biosciences · 2020Review
- The Singularity of Cetacea Behavior Parallels the Complete Inactivation of Melatonin Gene Modules.Genes · 2019Article
- Melatonin Synthesis and Function: Evolutionary History in Animals and Plants.Frontiers in endocrinology · 2019Review
- The origins of the circumventricular organs.Journal of anatomy · 2018Review
- Eis, a novel family of arylalkylamine N-acetyltransferase (EC 2.3.1.87).Scientific reports · 2018Article
- Daily Rhythm in Plasma N-acetyltryptamine.Journal of biological rhythms · 2017Article
- Degradation of Serotonin N-Acetyltransferase, a Circadian Regulator, by the N-end Rule Pathway.The Journal of biological chemistry · 2016Article
- Evolution and expression of the phosphodiesterase 6 genes unveils vertebrate novelty to control photosensitivity.BMC evolutionary biology · 2016Article
- Evolutionary diversification of retinoic acid receptor ligand-binding pocket structure by molecular tinkering.Royal Society open science · 2016Article
- Melatonin-Producing Endophytic Bacteria from Grapevine Roots Promote the Abiotic Stress-Induced Production of Endogenous Melatonin in Their Hosts.Frontiers in plant science · 2016Article
- Molecular Evolution of Aralkylamine N-Acetyltransferase in Fish: A Genomic Survey.International journal of molecular sciences · 2015Article
- Probing the chemical mechanism and critical regulatory amino acid residues of Drosophila melanogaster arylalkylamine N-acyltransferase like 2.Insect biochemistry and molecular biology · 2015Article
Corrections and comments
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Authors and funding
16 authors at 9 institutions in 5 countries.
Funding
Abstract
Melatonin (N-acetyl-5-methoxytrypamine) is the vertebrate hormone of the night: circulating levels at night are markedly higher than day levels. This increase is driven by precisely regulated increases in acetylation of serotonin in the pineal gland by arylalkylamine N-acetyltransferase (AANAT), the penultimate enzyme in the synthesis of melatonin. This unique essential role of AANAT in vertebrate timekeeping is recognized by the moniker the timezyme. AANAT is also found in the retina, where melatonin is thought to play a paracrine role. Here, we focused on the evolution of AANAT in early vertebrates. AANATs from Agnathans (lamprey) and Chondrichthyes (catshark and elephant shark) were cloned, and it was found that pineal glands and retinas from these groups express a form of AANAT that is compositionally, biochemically, and kinetically similar to AANATs found in bony vertebrates (VT-AANAT). Examination of the available genomes indicates that VT-AANAT is absent from other forms of life, including the Cephalochordate amphioxus. Phylogenetic analysis and evolutionary rate estimation indicate that VT-AANAT evolved from the nonvertebrate form of AANAT after the Cephalochordate-Vertebrate split over one-half billion years ago. The emergence of VT-AANAT apparently involved a dramatic acceleration of evolution that accompanied neofunctionalization after a duplication of the nonvertebrate AANAT gene. This scenario is consistent with the hypotheses that the advent of VT-AANAT contributed to the evolution of the pineal gland and lateral eyes from a common ancestral photodetector and that it was not a posthoc recruitment.
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