ArticleMarine drugs2013
Activation of the nuclear factor E2-related factor 2 pathway by novel natural products halomadurones A-D and a synthetic analogue.
Article in Marine drugs, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Chemistry and biology of specialized metabolites produced byNatural product reports · 2024Review
- Tunicates as Sources of High-Quality Nutrients and Bioactive Compounds for Food/Feed and Pharmaceutical Applications: A Review.Foods (Basel, Switzerland) · 2023Review
- Naturally Occurring Organohalogen Compounds-A Comprehensive Review.Progress in the chemistry of organic natural products · 2023Review
- Natural Products from Actinomycetes Associated with Marine Organisms.Marine drugs · 2021Review
- A Review: Halogenated Compounds from Marine Actinomycetes.Molecules (Basel, Switzerland) · 2021Review
- Phallusialides A-E, Pyrrole-Derived Alkaloids Discovered from a Marine-DerivedJournal of natural products · 2019Article
- Origins and Bioactivities of Natural Compounds Derived from Marine Ascidians and Their Symbionts.Marine drugs · 2019Review
- Madurastatin D1 and D2, Oxazoline Containing Siderophores Isolated from anOrganic letters · 2019Article
- Marine Rare Actinomycetes: A Promising Source of Structurally Diverse and Unique Novel Natural Products.Marine drugs · 2019Review
- Biological and Chemical Diversity of Ascidian-Associated Microorganisms.Marine drugs · 2018Review
- Marine Natural Product Honaucin A Attenuates Inflammation by Activating the Nrf2-ARE Pathway.Journal of natural products · 2018Article
- Chemical Genomics, Structure Elucidation, and in Vivo Studies of the Marine-Derived Anticlostridial Ecteinamycin.ACS chemical biology · 2017Article
- Review
- Natural Product Discovery Using Planes of Principal Component Analysis in R (PoPCAR).Metabolites · 2017Article
- Marine Rare Actinobacteria: Isolation, Characterization, and Strategies for Harnessing Bioactive Compounds.Frontiers in microbiology · 2017Review
- Forazoline A: marine-derived polyketide with antifungal in vivo efficacy.Angewandte Chemie (International ed. in English) · 2014Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Two novel chlorinated pyrones, halomadurones A and B, and two novel brominated analogues, halomadurones C and D, were isolated from a marine Actinomadura sp. cultivated from the ascidian Ecteinascidia turbinata. Additionally, a non-halogenated analogue, 2-methyl-6-((E)-3-methyl-1,3-hexadiene)-γ-pyrone, was synthesized to understand the role of the halogens for activity. Halomadurones C and D demonstrated potent nuclear factor E2-related factor antioxidant response element (Nrf2-ARE) activation, which is an important therapeutic approach for treatment of neurodegenerative diseases.
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