ArticleInternational journal of molecular sciences2013
Anti-inflammatory effects of 4-methylcyclopentadecanone on edema models in mice.
Article in International journal of molecular sciences, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 48 citations in OpenAlex.
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- Ameliorative effects of Mucuna imbricata on inflammation and oxidative stress in a rat edema model.Inflammopharmacology · 2026Article
- Discovery and characterization of phenoxyacetic acid derivatives as potential antiepileptic agents.RSC advances · 2025Article
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- Alcoholic extracts of Teucrium polium exhibit remarkable anti-inflammatory activity: In vivo study.Biomolecules & biomedicine · 2024Article
- Targeted Nanocarriers for Systemic Delivery of IRAK4 Inhibitors to Inflamed Tissues.Small (Weinheim an der Bergstrasse, Germany) · 2024Article
- ASPP 092, a phenolic diarylheptanoid fromSaudi journal of biological sciences · 2021Article
- Evidence of anti-inflammatory activity of Schizandrin A in animal models of acute inflammation.Naunyn-Schmiedeberg's archives of pharmacology · 2020Article
- Molecular Insight into the Anti-Inflammatory Effects of the Curcumin Ester Prodrug Curcumin Diglutaric Acid In Vitro and In Vivo.International journal of molecular sciences · 2020Article
- Antioxidant and anti-inflammatory properties ofHeliyon · 2020Article
- Muscone reduced the hypnotic and analgesic effect of ketamine in mice.Journal of the Chinese Medical Association : JCMA · 2020Article
- Antibacterial, anti-inflammatory and peroxidase-mediated cyclooxygenase-1 inhibitory properties ofPharmaceutical biology · 2019Article
- Simultaneous purification of dihydrotanshinone, tanshinone I, cryptotanshinone, and tanshinone IIA from Salvia miltiorrhiza and their anti-inflammatory activities investigation.Scientific reports · 2018Article
- Isoacteoside, a dihydroxyphenylethyl glycoside, exhibits anti-inflammatory effects through blocking toll-like receptor 4 dimerization.British journal of pharmacology · 2017Article
- Total tanshinones exhibits anti-inflammatory effects through blocking TLR4 dimerization via the MyD88 pathway.Cell death & disease · 2017Article
- Anti-hyperalgesic and Anti-inflammatory Activity of Alternanthera Maritima Extract and 2″-O-α-L-rhamnopyranosylvitexin in Mice.Inflammation · 2015Article
- The TRPA1 channel mediates the analgesic action of dipyrone and pyrazolone derivatives.British journal of pharmacology · 2015Article
- Development and evaluation of curcumin-loaded elastic vesicles as an effective topical anti-inflammatory formulation.AAPS PharmSciTech · 2015Article
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The present study evaluated the anti-inflammatory effects of 4-methylcyclopentadecanone (4-MCPC) on edema models in mice and aimed to determine the safety of 4-MCPC after acute exposure. The acute toxicity of 4-MCPC was evaluated by oral administration to rats of single doses of 0, 5, 50, 500 and 5000 mg/kg. Toxic symptoms were observed for 14 days. The anti-inflammatory activity was evaluated in xylene-induced mouse ear edema and carrageenan-induced mouse paw edema. The animals were treated with 4-MCPC once every day for seven consecutive days. Edema index, % inhibition, IL-1β, TNF-α, PGE2 and MPO levels in paws were detected after the treatment with xylene or carrageenan. Our results indicated that the LD50 value of 4-MCPC in rats is greater than 5000 mg/kg. The ED50 of 4-MCPC in xylene-induced mouse ear edema model was 7.5 mg/kg. 4-MCPC (8 or 16 mg/kg) remarkably inhibited carrageenan-induced mouse paw edema. Further study revealed that 4-MCPC treatment also decreased IL-1β, TNF-α, PGE2 and MPO levels in mice paws. Intragastric administration of 4-MCPC exhibited more significant anti-inflammatory activity than muscone at a dose of 16 mg/kg. Taken together, our results suggest that 4-MCPC has potent anti-inflammatory activity and the mechanisms might be related to the decreases of the levels of IL-1β, TNF-α, PGE2 and MPO in inflamed paws.
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