ArticleJournal of the American Association for Laboratory Animal Science : JAALAS2013
Incidence rates of spontaneous disease in laboratory mice used at a large biomedical research institution.
Article in Journal of the American Association for Laboratory Animal Science : JAALAS, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 35 citations in OpenAlex.
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- Effects of Compressed Paper Bedding on Mouse Breeding Performance and Recognition of Animal Health Concerns.Journal of the American Association for Laboratory Animal Science : JAALAS · 2021Article
- Identification of Sick or Dead Mice (Journal of the American Association for Laboratory Animal Science : JAALAS · 2021Article
- The epidemiology of fighting in group-housed laboratory mice.Scientific reports · 2020Article
- Automated and Continuous Monitoring of Animal Welfare through Digital Alerting.Comparative medicine · 2020Article
- The effect of group size, age and handling frequency on inter-male aggression in CD 1 mice.Scientific reports · 2020Article
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- Group and Single Housing of Male Mice: Collected Experiences from Research Facilities in Sweden.Animals : an open access journal from MDPI · 2019Article
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Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A detailed epidemiologic survey of spontaneous diseases of mice used in biomedical research has not been performed in more than 4 decades. The current study examined all mouse disease reports for a subset of the University of Pennsylvania vivaria from October 2010 through September 2011. Mortality logs were examined over the same period of time. After eliminating protocol-related cases, the incidence rates for more than 30 diseases were calculated in terms of number of cases per 1000 cages per month. The average daily census for the facilities analyzed exceeded 29,000 cages and included more than 180 research groups. No single research group accounted for more than 4% of the total number of cases reported, indicating that this study did not simply quantify the spontaneous disease incidence in a limited number of research groups. Spontaneous mortality with unknown cause in adult and neonatal mice without prior reported illness was the most commonly reported issue, followed by dermatitis, ocular disease, and nonspecific clinical signs including lethargy, poor hair coat, and muscle wasting. These results indicate that improving the ability to identify sick mice is important in refining the care and use of mice in biomedical research. The information provided in the current study can help to provide a baseline for comparison, guide the field in directing mouse welfare research toward areas of need, and identify optimal methods of care for mice in biomedical research.
Indexed as
Identifiers
24351767PMC3838613W2283688287What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.