Evidence map›Paper›PMID 24351766›Full record

ArticleJournal of the American Association for Laboratory Animal Science : JAALAS2013

Evaluation of diagnostic methods for Myocoptes musculinus according to age and treatment status of mice (Mus musculus).

Kelly A Rice, Lauren K Albacarys, Kelly A Metcalf Pate, Cheryl Perkins, Kenneth S Henderson, Julie Watson

Open access · greenAbstract readComparative StudyEvaluation Study
In one paragraph

Article in Journal of the American Association for Laboratory Animal Science : JAALAS, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
1.0field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Assembly of a Draft Genome for the Mouse EctoparasiteJournal of the American Association for Laboratory Animal Science : JAALAS · 2023
    Article
  6. PCR and RT-PCR in the Diagnosis of Laboratory Animal Infections and in Health Monitoring.Journal of the American Association for Laboratory Animal Science : JAALAS · 2020
    Article
  7. Detection ofJournal of the American Association for Laboratory Animal Science : JAALAS · 2019
    Article
  8. Article
  9. Ivermectin-compounded Feed Compared with Topical Moxidectin-Imidacloprid for Eradication ofJournal of the American Association for Laboratory Animal Science : JAALAS · 2018
    Article
  10. Comparison of Diagnostic Methods and Sampling Sites for the Detection of Demodex musculi.Journal of the American Association for Laboratory Animal Science : JAALAS · 2018
    Article
  11. PCR Testing of IVC Filter Tops as a Method for Detecting Murine Pinworms and Fur Mites.Journal of the American Association for Laboratory Animal Science : JAALAS · 2017
    Article
  12. Characterization ofComparative medicine · 2017
    Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Kelly A RiceDepartment of Molecular and Comparative Pathobiology, Johns Hopkins School of Medicine, Baltimore, Maryland, USA; Division of Veterinary Resources, National Institutes of Health, Poolesville, Maryland, USA. kelly.rice@nih.gov.
Lauren K AlbacarysResearch Animal Resources, Johns Hopkins School of Medicine, Baltimore, Maryland, USA.
Kelly A Metcalf PateDepartment of Molecular and Comparative Pathobiology, Johns Hopkins School of Medicine, Baltimore, Maryland, USA.
Cheryl PerkinsResearch Animal Diagnostic Services, Charles River, Wilmington, Massachusetts, USA.
Kenneth S HendersonResearch Animal Diagnostic Services, Charles River, Wilmington, Massachusetts, USA.
Julie WatsonDepartment of Molecular and Comparative Pathobiology, Johns Hopkins School of Medicine, Baltimore, Maryland, USA.
Johns Hopkins Medicine · US

Funding

Training Veterinarians for Careers in Biomedical ResearchT32OD011089 · OD · JOHNS HOPKINS UNIVERSITY · PI JOSEPH L MANKOWSKI · 2012 to 2026
$6.7M
Research Education Program for LAM Veterinarians at Johns Hopkins UniversityR25OD010913 · OD · JOHNS HOPKINS UNIVERSITY · PI ADAMS, ROBERT J. · 2012 to 2014
$576k
NIH HHS R25 OD010913NIH HHS T32 OD011089
6 · The paper itself

Abstract

Detecting and controlling murine fur mites continues to be challenging. Here we compared the efficacy of fur-pluck, cage PCR, and fur PCR testing of mice naturally infested with Myocoptes musculinus and make recommendations regarding the application of these diagnostic strategies in aged or treated mice. We compared all 3 diagnostic methods in groups of infested and noninfested control mice over time. For fur plucks, we used a scoring system to quantitatively compare mite infestations across ages. Mice that were 4 wk old had higher egg and mite scores than did older mice, with average scores at 4 wk corresponding to 40 to 100 individual fur mites and eggs per sample. Furthermore, 15% and 20% of samples from infested mice at 24 and 28 wk of age, respectively, lacked all fur mites and eggs. Cage PCR results varied as mice grew older. Fur PCR testing was the most sensitive and specific assay in untreated infested mice, particularly when mite densities were low. In addition, we compared fur-pluck and fur PCR tests for evaluating the efficacy of selamectin treatment. Two treatments with selamectin eliminated Myocoptes fur-mite infestations. At 8 wk after treatment, all fur-pluck samples were negative, but one-third of treated infested cages remained positive by fur PCR assay; at 16 wk after treatment, all cages were negative by fur PCR assay. Because offspring of infested mice were invariably heavily infested, breeding of suspected infested mice with subsequent testing of offspring was the definitive testing strategy when fur-pluck and PCR results conflicted.

Indexed as

MiceMitesAnimalsAntiparasitic AgentsFemaleIvermectinMaleMite InfestationsPolymerase Chain ReactionRodent DiseasesSensitivity and SpecificityAntiparasitic AgentsIvermectinselamectin

Identifiers

PMID24351766
PMCPMC3838612
OpenAlexW2207582296

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.